FOLR4 蛋白, Human (HEK293, His)

The FOLR4 protein serves as a receptor for IZUMO1 on the egg membrane and plays a crucial role in species-specific gamete recognition and fertilization. The interaction between IZUMO1 and FOLR4 (IZUMO1R/JUNO) is an important adhesion event that is required for fertilization but not sufficient for cell fusion. FOLR4 Protein, Human (HEK293, His) is the recombinant human-derived FOLR4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR4 Protein, Human (HEK293, His) is 209 a.a., with molecular weight of 30-35 kDa.

FOLR4 蛋白作为卵母细胞表面 (oolemma) 的 IZUMO1 受体，在物种特异性配子识别和受精中发挥至关重要的作用。IZUMO1 与其受体 FOLR4（称为 IZUMO1R/JUNO）之间的相互作用是精子和卵子之间的重要粘附事件，是受精所必需的，尽管它本身不足以进行细胞融合。与它的名字相反，FOLR4 不结合叶酸，并且它的配体-受体相互作用不被归类为膜“融合剂”。FOLR4 作为单体存在，直接与 IZUMO1 相互作用，形成化学计量比为 1:1 的复合物。有趣的是，FCRL3/MAIA在精卵粘附后取代IZUMO1R/JUNO作为IZUMO1的受体，促进物种特异性配子融合。这些相互作用凸显了受精过程中配子识别和融合的复杂分子机制。

Human

HEK293

C-His

A6ND01-1 (G20-S228)

390243  [NCBI]

30-35 kDa

Greater than 95% as determined by Tris-Bis PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.