FOXP3 蛋白, Human (His)

FOXP3 is a key transcriptional regulator essential for the development and function of regulatory T cells (Tregs), ensuring immune system homeostasis. It acts as a dual repressor and activator, regulating Treg suppressive function and stability while affecting conventional T cell expansion. FOXP3 Protein, Human (His) is the recombinant human-derived FOXP3 protein, expressed by E. coli , with N-His labeled tag.

FOXP3 是一种关键的转录调节因子，对于调节性 T 细胞 (Treg) 的发育和抑制功能不可或缺，在维持免疫系统稳态中发挥着至关重要的作用。它既是转录抑制子又是激活子，影响 Treg 谱系的抑制功能和稳定性，同时调节传统 T 细胞的扩增和功能。FOXP3 协调 CTLA4 和 TNFRSF18 等关键基因的激活，同时抑制白介素 2 (IL2) 和干扰素 γ (IFNG) 等细胞因子编码基因。通过与各种转录因子和染色质修饰剂的结合，FOXP3 抑制细胞因子的产生、T 细胞效应功能以及产生 IL17 的辅助 T 细胞 (Th17) 的分化，从而有利于 Treg 的发育。FOXP3 与 IKZF3、RUNX1、RORC、RELA、NFATC2 等蛋白质的相互作用有助于其多样化的调节功能。二聚化对其转录调节活性至关重要，它与 STUB1、HSPA8、PPP1CA、PPP1CB、KAT5、HDAC7、USP7、ZFP90、TRIM28、RUNX2、RUNX3 和 IKZF4 等蛋白质形成复合物。

Human

E. coli

N-His

Q9BZS1-1 (M1-L260)

50943  [NCBI]

MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHL

Approximately 31.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.