Fractalkine/CX3CL1 蛋白, Human (Biotinylated, HEK293, His)

Fractalkine/CX3CL1 is a chemokine that acts as a ligand to CX3CR1 and the integrins ITGAV: ITGB3 and ITGA4: ITGB1. CX3CL1 promotes lung cancer cell migration and invasion through the Src/FAK signaling pathway. CX3CL1 plays an important role in immune response, inflammation, cell adhesion and chemotaxis. Fractalkine/CX3CL1 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Fractalkine/CX3CL1 protein, expressed by HEK293 , with C-Avi, C-10*His labeled tag.

Fractalkine/CX3CL1 是一种趋化因子，作为 CX3CR1 和整合素 ITGAV: ITGB3 和 ITGA4: ITGB1 的配体。CX3CR1-CX3CL1 信号在不同的组织区室中发挥不同的功能，如免疫应答、炎症、细胞粘附和趋化。CX3CL1 可调节内皮细胞的粘附和迁移过程，通过 CX3CR1 依赖性和 CXCR1 非依赖性激活整合素。CX3CL1 通过 Src/FAK 信号通路促进肺癌细胞迁移和侵袭。

Human

HEK293

C-Avi;C-10*His

P78423/AAH01163 (Q25-Q341)

6376  [NCBI]

50-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.