CX3CL1 - C-X3-C motif chemokine ligand 1 Gene

中文名称：C-X3-C 基序趋化因子配体 1

种属: Homo sapiens

同用名: NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin

基因 ID: 6376 | 基因类型: protein coding

关于 CX3CL1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,372,490-57,385,044 (from NCBI)

This gene has 4 transcripts (splice variants), 155 orthologues and 25 paralogues. Broad expression in brain (RPKM 40.1), lung (RPKM 37.8) and 21 other tissues.

功能概要

该基因属于趋化因子的 CX3C 亚组，其特征在于位于保守半胱氨酸残基之间的氨基酸数量。这是 CX3C 亚组的唯一成员，它在半胱氨酸残基之间包含三个氨基酸，从而形成 Cys-XXX-Cys 构型。编码的蛋白质包含一个延伸的粘蛋白样茎，顶部有一个趋化因子结构域，并且以膜锚定形式存在，它充当结合分子，或者以可溶形式存在，作为趋化细胞因子。这种蛋白质的成熟形式可以在细胞表面被切割，产生可以与 G 蛋白偶联受体、C-X3-C 基序趋化因子受体 1 基因产物相互作用的不同可溶形式。该基因在多种疾病中发挥作用，包括癌症、血管炎、神经病、动脉粥样硬化、炎症性疾病和人类免疫缺陷病毒感染。[RefSeq 提供，2017 年 9 月]

This gene belongs to the CX3C subgroup of chemokines, characterized by the number of Amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three Amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif Chemokine Receptor 1 gene product. This gene plays a role in a wide range of diseases, including Cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017]

CX3CL1 基因产物(2)

mRNA	Protein	Name
NM_001304392.3	NP_001291321.1	fractalkine isoform 2
NM_002996.6	NP_002987.1	fractalkine isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables CX3C chemokine receptor binding	IDA IDA: 通过直接分析推断	10415068	GOA
enables CXCR1 chemokine receptor binding	IPI IPI: 通过物理相互作用推断	10187784	GOA
enables chemoattractant activity	IMP IMP: 通过突变表型推断	10899174	GOA
enables chemokine activity	IDA IDA: 通过直接分析推断	21829356	GOA
enables chemokine activity	IGI IGI: 通过遗传相互作用推断	10415068	GOA
enables integrin binding	IDA IDA: 通过直接分析推断	23125415	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9931005	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell adhesion	IPI IPI: 通过物理相互作用推断	10187784	GOA
involved in cell chemotaxis	IDA IDA: 通过直接分析推断	10415068	GOA
involved in chemokine-mediated signaling pathway	IDA IDA: 通过直接分析推断	10415068	GOA
involved in chemokine-mediated signaling pathway	IGI IGI: 通过遗传相互作用推断	10869418	GOA
involved in chemotaxis	IDA IDA: 通过直接分析推断	21829356	GOA
involved in chemotaxis	IMP IMP: 通过突变表型推断	23125415	GOA
involved in integrin activation	IMP IMP: 通过突变表型推断	23125415	GOA
involved in leukocyte migration involved in inflammatory response	IMP IMP: 通过突变表型推断	23125415	GOA
involved in microglial cell proliferation	IMP IMP: 通过突变表型推断	12125082	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	24294368	GOA
involved in negative regulation of apoptotic signaling pathway	IGI IGI: 通过遗传相互作用推断	10869418	GOA
involved in negative regulation of cell migration	IDA IDA: 通过直接分析推断	25435433	GOA
involved in negative regulation of hippocampal neuron apoptotic process	IGI IGI: 通过遗传相互作用推断	10869418	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: 通过直接分析推断	10652441	GOA
involved in positive chemotaxis	IMP IMP: 通过突变表型推断	10899174	GOA
involved in positive regulation of I-kappaB phosphorylation	IGI IGI: 通过遗传相互作用推断	10869418	GOA
involved in positive regulation of MAPK cascade	IGI IGI: 通过遗传相互作用推断	10415068	GOA
involved in positive regulation of actin filament bundle assembly	IGI IGI: 通过遗传相互作用推断	10415068	GOA
involved in positive regulation of calcium-independent cell-cell adhesion	IDA IDA: 通过直接分析推断	12714508	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: 通过遗传相互作用推断	10869418	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	24294368	GOA
involved in positive regulation of inflammatory response	IEP IEP: 通过表达模式推断	11777952	GOA
involved in positive regulation of microglial cell migration	IDA IDA: 通过直接分析推断	10415068	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: 通过遗传相互作用推断	10415068	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IGI IGI: 通过遗传相互作用推断	10415068	GOA
involved in regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: 通过直接分析推断	10652441	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	12714508	GOA
located in extracellular region	IDA IDA: 通过直接分析推断	10415068	GOA
located in extracellular region	IMP IMP: 通过突变表型推断	10899174	GOA
located in membrane	IDA IDA: 通过直接分析推断	10899174	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CX3CL1 蛋白结构

IL8

0
100
200
300
397 a.a.

蛋白主名

其他名称

fractalkine

C-X3-C motif chemokine 1

CX3CL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CX3CL1	P78423	ITGB3	Homo sapiens	P05106	ELISA	24789099
种属内	CX3CL1	P78423	ITGB3	Homo sapiens	P05106	ELISA	23125415
种属内	CX3CL1	P78423	ITGB3	Homo sapiens	P05106	Pull Down	24789099

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CX3CL1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7180	Fractalkine/CX3CL1 Protein, Human	P78423 (Q25-G100)	≥95%
HY-P7355	Fractalkine/CX3CL1 Protein, Human (S199N, CHO)	P78423 (Q25-R339, S199N)	≥95%
HY-P72685	Fractalkine/CX3CL1 Protein, Human (315a.a, HEK293, His)	P78423 (Q25-R339)	≥95%
HY-P76938	Fractalkine/CX3CL1 Protein, Cynomolgus (HEK293, Fc)	EHH60415.1 (Q25-G100)	≥95%
HY-P76939	Fractalkine/CX3CL1 Protein, Cynomolgus (HEK293, His)	EHH60415.1 (Q25-G100)	≥95%
HY-P78937	Fractalkine/CX3CL1 Protein, Human (Biotinylated, HEK293, His)	P78423/AAH01163 (Q25-Q341)	≥95%

关联疾病

疾病名称

别名

Pityriasis Rosea

Pityriasis Circinata

Gibert Pityriasis

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Chorioretinitis

Retinochoroiditis

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Neuritis

Peripheral Neuritis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Chronic Cholangitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Retinal Degeneration

Degeneration Of Retina

Refractory Plasma Cell Neoplasm

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03378	CX3CL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99404	Quetmolimab	Inhibitor	95.00%	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CX3CL1	VGNC	VGNC:61296
Mus musculus	CX3CL1	MGD	MGI:1097153
Rattus norvegicus	CX3CL1	RGD	RGD:620458
Canis familiaris	CX3CL1	VGNC	VGNC:39745
Bos taurus	CX3CL1	VGNC	VGNC:52190
Macaca mulatta	CX3CL1	VGNC	VGNC:71395
Macaca fascicularis	CX3CL1	NCBI	NCBI:102117496
Others	CX3CL1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CX3CL1 - C-X3-C motif chemokine ligand 1 Gene

关于 CX3CL1

功能概要

CX3CL1 基因产物(2)

CX3CL1 蛋白结构

CX3CL1 蛋白互作信息

重组 CX3CL1 蛋白

关联疾病

直系同源

热门区域

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CX3CL1 - C-X3-C motif chemokine ligand 1 Gene

关于 CX3CL1

功能概要

CX3CL1 基因产物(2)

CX3CL1 蛋白结构

CX3CL1 蛋白互作信息

重组 CX3CL1 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

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