Fusion glycoprotein F0/F 蛋白, HRSV (AHX57537, sf9, His)

F0/F is a class of viral fusion proteins that, as an inactive precursor, are cleaved by a furfurin-like protease at two sites to produce mature F1 and F2 fusion glycoproteins.The F protein can mediate cell-cell fusion, lead to syncytial formation, and trigger p53-dependent apoptosis in the later stages of infection.Fusion glycoprotein F0/F Protein, HRSV (AHX57537, sf9, His) is the recombinant Virus-derived Fusion glycoprotein F0/F protein, expressed by Sf9 insect cells , with C-His labeled tag.

融合糖蛋白 F0/F 是一类病毒融合蛋白，作为一个无活性的前体，在两个位点被一种类似糠蛋白的蛋白酶切割，生成成熟的 F1 和 F2 融合糖蛋白。F1-F2 三聚体 (F 蛋白) 发挥双重作用，通过与宿主硫酸肝素结合帮助附着于宿主细胞，并通过与宿主 IGFR1 相互作用促进进入宿主细胞。F 蛋白可以介导细胞-细胞融合，导致合胞体形成，F 蛋白可能在感染后期触发 p53 依赖性细胞凋亡。

Virus

Sf9 insect cells

C-His

AHX57537 (Q26-M526)

/

Approximately 57.04 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.