GABARAP 蛋白, Human (His, Fc)

GABARAP (gamma-aminobutyric acid receptor-associated protein) is a protein that performs multiple functions within cells. As a ubiquitin-like modifier, it participates in the intracellular transport of GABA(A) receptors and interacts with the cytoskeleton. GABARAP Protein, Human (His, Fc) is the recombinant human-derived GABARAP protein, expressed by E. coli , with N-His, C-hFc labeled tag. The total length of GABARAP Protein, Human (His, Fc) is 117 a.a., with molecular weight of ~50 kDa.

GABARAP（γ-氨基丁酸受体相关蛋白）是一种在细胞内发挥多种功能的蛋白质。它作为泛素样修饰剂，参与 GABA(A) 受体的细胞内转运并与细胞骨架相互作用。GABARAP 参与自噬，特别是在自噬体成熟的后期阶段。它与网状吞噬受体 TEX264 相互作用，将内质网的子结构域重塑为自噬体，然后与溶酶体合并以实现内质网的周转。GABARAP 对于 CUL3(KBTBD6/7) E3 泛素连接酶复合物的局部激活也至关重要，该复合物调节鸟苷酸交换因子 TIAM1 的泛素化和降解。TIAM1 的降解会影响参与细胞迁移、增殖和细胞骨架组织的下游信号转导途径。此外，GABARAP 与细胞凋亡有关。总体而言，GABARAP 在各种生物过程中发挥着至关重要的作用，包括细胞内运输、自噬、细胞骨架组织和细胞信号传导。

Human

E. coli

N-6*His;C-hFc

Q6IAW1 (M1-L117)

11337  [NCBI]

MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL

Approximately 50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, 20% glycerol, pH 7.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.