GABARAP - GABA type A receptor-associated protein Gene

中文名称：GABA A 型受体相关蛋白

种属: Homo sapiens

同用名: MM46; ATG8A; GABARAP-a

基因 ID: 11337 | 基因类型: protein coding

关于 GABARAP

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,240,008-7,242,449 (from NCBI)

This gene has 6 transcripts (splice variants), 133 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 212.0), ovary (RPKM 206.1) and 25 other tissues.

功能概要

γ-氨基丁酸 A 受体 [GABA (A) 受体] 是介导抑制性神经传递的配体门控氯离子通道。该基因编码 GABA (A) 受体相关蛋白，其 N 末端带正电荷，与微管相关蛋白 1A 和 1B 的轻链 3 具有序列相似性。这种蛋白质通过介导与细胞骨架的相互作用来聚集神经递质受体。[RefSeq 提供，2008 年 7 月]

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with LIGHT chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the Cytoskeleton. [provided by RefSeq, Jul 2008]

GABARAP 基因产物(1)

mRNA	Protein	Name
NM_007278.2	NP_009209.1	gamma-aminobutyric acid receptor-associated protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GABA receptor binding	IPI IPI: 通过物理相互作用推断	9892355	GOA
enables beta-tubulin binding	IDA IDA: 通过直接分析推断	9892355	GOA
enables phosphatidylethanolamine binding	IDA IDA: 通过直接分析推断	15169837	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9892355	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	25127057	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: 通过直接分析推断	15977068	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	25684205	GOA
involved in positive regulation of protein K48-linked ubiquitination	IMP IMP: 通过突变表型推断	25684205	GOA
involved in regulation of Rac protein signal transduction	IMP IMP: 通过突变表型推断	25684205	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in autophagosome	IDA IDA: 通过直接分析推断	19056683	GOA
located in autophagosome membrane	IDA IDA: 通过直接分析推断	15169837	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GABARAP 蛋白结构

Atg8

0
100
117 a.a.

蛋白主名

其他名称

gamma-aminobutyric acid receptor-associated protein

GABA(A) receptor-associated protein

重组 GABARAP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70861	GABARAP Protein, Human (GST)	Q6IAW1 (M1-L117)	≥95%
HY-P72639	GABARAP Protein, Human (His, Fc)	Q6IAW1 (M1-L117)	≥95%
HY-P76942	GABARAP Protein, Human (His-MBP)	O95166 (M1-L117)	≥95%

关联疾病

疾病名称

别名

Stiff-Person Syndrome

SPS	Stiff-Man Syndrome
Stiff Man Syndrome	Stiff Person Syndrome
Moersch-Woltman Syndrome	Sms
Stiff-Trunk Syndrome	Morsch Woltman Syndrome
Stiff Person Syndrome And Related Disorders	Stiff Person Spectrum Disorder
Classic Stiff Person Syndrome	Classic Sps
Focal Stiff Limb Syndrome	Focal Stiff-Person Syndrome
Stiff Leg Syndrome	Progressive Encephalomyelitis With Rigidity

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Retinitis Pigmentosa 84

RP84	Retinitis Pigmentosa, Type 84

Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I	Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome
Hsan1e	Hsan1
Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy	Hsn1e
Hsnie	Hereditary Sensory Neuropathy Type Ie
Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory And Autonomic Neuropathy Type 1e	Hereditary Sensory Neuropathy With Hearing Loss And Dementia
Dnmt1-Complex Disorder	Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss
Hsn Ie	Hereditary Sensory Autonomic Neuropathy, Type 1
Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-16121	CAA-0225	Inhibitor	/	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05201	GABARAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	GABARAP	RGD	RGD:61911
Mus musculus	GABARAP	MGD	MGI:1861742
Bos taurus	GABARAP	VGNC	VGNC:29185
Canis familiaris	GABARAP	VGNC	VGNC:41046
Felis catus	GABARAP	VGNC	VGNC:62414
Others	GABARAP	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GABARAP - GABA type A receptor-associated protein Gene

关于 GABARAP

功能概要

GABARAP 基因产物(1)

GABARAP 蛋白结构

重组 GABARAP 蛋白

关联疾病

直系同源

热门区域

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GABARAP - GABA type A receptor-associated protein Gene

关于 GABARAP

功能概要

GABARAP 基因产物(1)

GABARAP 蛋白结构

重组 GABARAP 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z