2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. CAA-0225

CAA-0225 是一种有效的组织蛋白酶 (Cathepsin) L 抑制剂。CAA-0225 抑制大鼠肝组织蛋白酶 L，IC50 值为 1.9 nM。在自噬研究中，CAA-0225 可有效抑制 HeLa 和 Huh-7 细胞在营养缺乏条件下长寿命蛋白质的降解。CAA-0225 还能抑制自噬体膜标记物（如 LC3-II 和 GABARAP-II）的降解，表明其作用是阻断与这些标记物相关的降解过程，而不是一般的溶酶体蛋白降解。

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CAA-0225 Chemical Structure

CAA-0225 Chemical Structure

CAS No. : 244072-26-2

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CAA-0225 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3].
IC50 & Target

cathepsin L

 

体外研究
(In Vitro)

CAA-0225 (10 mg/mL, 4 h) 通过特异性抑制组织蛋白酶L参与自噬体膜标志物LC3-II 和GABARAP的降解从而作为自噬蛋白水解探针[1]。
CAA-0225 (0-100 μM, 48 h) 通过抑制组织蛋白酶L来杀灭布氏锥虫寄生虫[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAA-0225 相关抗体:

Western Blot Analysis[1].

Cell Line: HeLa、Huh-7 cells
Concentration: 10 mg/mL
Incubation Time: 4 h
Result: Inhibited the degradation of microtubule associated protein IA/IB light chain 3-II (LC3-II) and gamma aminobutyric acid (A) receptor associated protein (GABARAP)-II

Cell Proliferation Assay[3].

Cell Line: Bloodstream forms of T. brucei clone 427–221a
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Inhibited the growth of trypanosomes in a dose-dependent manner with GI50 values of 0.33 μM, respectively
体内研究
(In Vivo)

CAA-0225 (0.25 mg, 静脉注射) 通过抑制心肌梗死后再灌注小鼠模型中心肌组织蛋白酶- L 的释放来改善心脏功能并减少梗死面积[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Model of reperfusion injury involved male C57Bl/6 mice aged 9–12 weeks[2].
Dosage: 0.25 mg
Administration: Intravenous injection (i.v.)
Result: Reduced infarct size, improved systolic and diastolic cardiac function.
分子量

487.55

Formula

C28H29N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CAA-0225 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAA-0225244072-26-2CAA0225CAA 0225Cathepsinautophagycardiac functionHeLa cellHuh-7 celltrypanosoma bruceiInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-16121
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