2. Gene
  3. FNIP1 - folliculin interacting protein 1 Gene

FNIP1 - folliculin interacting protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：卵泡素相互作用蛋白 1

种属: Homo sapiens

同用名: IMD93

基因 ID: 96459 | 基因类型: protein coding

关于 FNIP1

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:131,641,714-131,797,017 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 9.3), thyroid (RPKM 7.7) and 25 other tissues.

功能概要

该基因编码的蛋白质可与肿瘤抑制蛋白卵泡蛋白和 AMP 活化蛋白激酶 (AMPK) 结合。编码的蛋白质通过调节 AMPK 和雷帕霉素信号通路的靶标参与细胞代谢和营养感应的调节。该基因有一个密切相关的旁系同源基因，它编码一种具有相似结合活性的蛋白质。这两种相关蛋白还与分子伴侣热休克蛋白 90 (HSP90) 相关联，负向调节其 ATP 酶活性并促进其与卵泡蛋白的结合。[RefSeq 提供，2017 年 7 月]

This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (HSP90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

FNIP1 基因产物(4)

mRNA Protein Name
NM_001008738.3 NP_001008738.3 folliculin-interacting protein 1 isoform 2
NM_001346113.2 NP_001333042.2 folliculin-interacting protein 1 isoform 3
NM_001346114.2 NP_001333043.1 folliculin-interacting protein 1 isoform 4
NM_133372.3 NP_588613.3 folliculin-interacting protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase inhibitor activity IDA
IDA: 通过直接分析推断
27353360 GOA
enables enzyme activator activity IDA
IDA: 通过直接分析推断
24081491 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
30699359 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17028174 GOA
enables protein-folding chaperone binding IDA
IDA: 通过直接分析推断
27353360 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell differentiation IMP
IMP: 通过突变表型推断
32905580 GOA
involved in TOR signaling IMP
IMP: 通过突变表型推断
17028174 GOA
involved in negative regulation of lysosome organization IDA
IDA: 通过直接分析推断
37079666 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21209915 GOA
involved in positive regulation of TOR signaling IDA
IDA: 通过直接分析推断
24081491 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
24081491 GOA
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
19914239 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
17028174 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
25126726 GOA
involved in regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
18663353 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17028174 GOA
located in cytosol IDA
IDA: 通过直接分析推断
24081491 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
24081491 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FNIP1 蛋白结构

FNIP_N

FNIP_N: Folliculin-interacting protein N-terminus (41 - 163)

FNIP_M

FNIP_M: Folliculin-interacting protein middle domain (314 - 550)

FNIP_C

FNIP_C: Folliculin-interacting protein C-terminus (975 - 1162)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1166 a.a.
蛋白主名 其他名称

folliculin-interacting protein 1

FNIP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FNIP1 Q8TF40 FLCN Homo sapiens Q8NFG4
Anti Tag CoIP
18403135
种属间
FNIP1 Q8TF40 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
种属内
FNIP1 Q8TF40 GABARAP Homo sapiens O95166
Pull Down
20562859
种属内
FNIP1 Q8TF40 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
种属内
FNIP1 Q8TF40 FNIP2 Homo sapiens Q9P278
Anti Tag CoIP
18403135
种属内
FNIP1 Q8TF40 FNIP2 Homo sapiens Q9P278
Pull Down
18403135
种属内
FNIP1 Q8TF40 FNIP2 Homo sapiens Q9P278
Anti Bait CoIP
18403135
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 93 And Hypertrophic Cardiomyopathy

IMD93
Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome

Fibrofolliculomas With Trichodiscomas And Acrochordons

BHD

Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculoma Familial

Bhd Syndrome

Birt Hogg Dube Syndrome

Hornstein-Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculomas
Multilocular Clear Cell Renal Cell Carcinoma

Cystadenocarcinoma Of Kidney

Renal Cystadenocarcinoma
Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax

Spontaneous Pneumothorax

Familial Spontaneous Pneumothorax

PSP

Pneumothorax
Familial Renal Oncocytoma
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary
Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin
Dermis Tumor

Dermis Tumour

Neoplasm Of Dermis

Tumor Of Dermis

Tumour Of Dermis
Hereditary Renal Cell Carcinoma
Renal Oncocytoma

Oncocytoma, Renal

Oncocytoma Of Kidney

Renal Epithelial Oncocytic Tumor

Oncocytoma Kidney

Oncocytoma Renal

Kidney Oncocytoma
Kidney Angiomyolipoma

Angiomyolipoma Of Kidney

Renal Angiomyolipoma
Kidney Benign Neoplasm

Renal And Ureteral Tumor

Benign Kidney Neoplasm
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W229874 EN106 Inhibitor 99.85% 否
HY-RS05023 FNIP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FNIP1 RGD RGD:2318339
Felis catus FNIP1 VGNC VGNC:62325
Mus musculus FNIP1 MGD MGI:2444668
Bos taurus FNIP1 VGNC VGNC:29068
Canis familiaris FNIP1 VGNC VGNC:40935
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