2. Gene
  3. FNIP2 - folliculin interacting protein 2 Gene

FNIP2 - folliculin interacting protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：卵泡素相互作用蛋白 2

种属: Homo sapiens

同用名: FNIPL; MAPO1

基因 ID: 57600 | 基因类型: protein coding

关于 FNIP2

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:158,769,026-158,908,050 (from NCBI)

This gene has 6 transcripts (splice variants), 145 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 11.0), fat (RPKM 8.4) and 25 other tissues.

功能概要

该基因编码一种与肿瘤抑制因子卵泡蛋白和 AMP 活化蛋白激酶 (AMPK) 结合的蛋白质，并可能通过调节雷帕霉素信号通路的 AMPK 机制靶点来发挥细胞代谢和营养感应的作用。编码的蛋白质也可能参与调节 O6-甲基鸟嘌呤诱导的细胞凋亡信号通路。该基因有一个密切相关的旁系同源基因，它编码一种具有相似结合活性的蛋白质。这两种相关蛋白还与分子伴侣热休克蛋白 90 (HSP90) 相关联，负向调节其 ATP 酶活性并促进其与卵泡蛋白的结合。[RefSeq 提供，2017 年 7 月]

This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced Apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (HSP90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

FNIP2 基因产物(4)

mRNA Protein Name
NM_001323916.2 NP_001310845.1 folliculin-interacting protein 2 isoform 2
NM_001346043.2 NP_001332972.1 folliculin-interacting protein 2 isoform 3
NM_001366843.1 NP_001353772.1 folliculin-interacting protein 2 isoform 4
NM_020840.3 NP_065891.1 folliculin-interacting protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase inhibitor activity IDA
IDA: 通过直接分析推断
27353360 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18403135 GOA
enables protein-folding chaperone binding IDA
IDA: 通过直接分析推断
27353360 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21209915 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
36103527 GOA
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
19914239 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
25126726 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
18663353 GOA
involved in regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
18663353 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FNIP-folliculin RagC/D GAP IDA
IDA: 通过直接分析推断
36103527 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18403135 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FNIP2 蛋白结构

FNIP_N

FNIP_N: Folliculin-interacting protein N-terminus (46 - 172)

FNIP_M

FNIP_M: Folliculin-interacting protein middle domain (295 - 532)

FNIP_C

FNIP_C: Folliculin-interacting protein C-terminus (926 - 1110)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1114 a.a.
蛋白主名 其他名称

folliculin-interacting protein 2

FNIP1-like protein

FNIP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FNIP2 Q9P278 FNIP1 Homo sapiens Q8TF40
Anti Tag CoIP
18403135
种属内
FNIP2 Q9P278 FLCN Homo sapiens Q8NFG4
Anti Tag CoIP
18403135
种属内
FNIP2 Q9P278 FLCN Homo sapiens Q8NFG4
Anti Bait CoIP
18403135
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome

Fibrofolliculomas With Trichodiscomas And Acrochordons

BHD

Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculoma Familial

Bhd Syndrome

Birt Hogg Dube Syndrome

Hornstein-Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculomas
Familial Renal Oncocytoma
Multilocular Clear Cell Renal Cell Carcinoma

Cystadenocarcinoma Of Kidney

Renal Cystadenocarcinoma
Oncocytoma

Oxyphilic Adenoma

Follicular Adenoma, Oxyphilic Cell

Adenoma, Oxyphilic

Hurthle Cell Tumor

Oncocytic Neoplasm
Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary
Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin
Dermis Tumor

Dermis Tumour

Neoplasm Of Dermis

Tumor Of Dermis

Tumour Of Dermis
Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax

Spontaneous Pneumothorax

Familial Spontaneous Pneumothorax

PSP

Pneumothorax
Hereditary Renal Cell Carcinoma
Renal Oncocytoma

Oncocytoma, Renal

Oncocytoma Of Kidney

Renal Epithelial Oncocytic Tumor

Oncocytoma Kidney

Oncocytoma Renal

Kidney Oncocytoma
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05024 FNIP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FNIP2 VGNC VGNC:100228
Mus musculus FNIP2 MGD MGI:2683054
Rattus norvegicus FNIP2 RGD RGD:1562174
Canis familiaris FNIP2 VGNC VGNC:40936
Bos taurus FNIP2 VGNC VGNC:29069
Felis catus FNIP2 VGNC VGNC:62326
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