ATG4B - autophagy related 4B cysteine peptidase Gene

中文名称：自噬相关的 4B 半胱氨酸肽酶

种属: Homo sapiens

同用名: APG4B; AUTL1; HsAPG4B

关于 ATG4B

功能概要

自噬是内源性蛋白质和受损细胞器在细胞内被破坏的过程。据推测，自噬对于分化、变态、非凋亡性细胞死亡和衰老过程中的细胞稳态和细胞重塑至关重要。在一些恶性肿瘤中已经描述了自噬水平降低，并且已经提出自噬在控制与癌症相关的不受调节的细胞生长中的作用。该基因编码自噬蛋白家族的一个成员。编码的蛋白质也被指定为半胱氨酸蛋白酶 C-54 家族的成员。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]