IPO5 - importin 5 Gene

中文名称：导入 5

种属: Homo sapiens

同用名: IMB3; Pse1; imp5; KPNB3; RANBP5

关于 IPO5

功能概要

核质运输是一种信号和能量依赖性过程，通过嵌入核膜中的核孔复合物发生。含有核定位信号 (NLS) 的蛋白质的输入需要 NLS 输入受体，即输入蛋白 alpha 和 beta 亚基的异二聚体，也称为 karyopherins。 Importin alpha 结合细胞质中含有 NLS 的货物，importin beta 将复合物停靠在核孔复合物的细胞质侧。在三磷酸核苷和小 GTP 结合蛋白 Ran 的存在下，复合物进入核孔复合物，输入蛋白亚基解离。 Importin alpha 与其乘客蛋白一起进入核质，而 importin beta 保留在孔隙中。 importin beta 和核孔蛋白的 FG 重复之间的相互作用对于通过孔复合物的易位至关重要。该基因编码的蛋白质是 importin beta 家族的成员。[RefSeq 提供，2008 年 7 月]

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]