RPL7 - ribosomal protein L7 Gene

中文名称：核糖体蛋白 L7

种属: Homo sapiens

同用名: L7; humL7-1

基因 ID: 6129 | 基因类型: protein coding

关于 RPL7

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,290,242-73,294,466 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 918.2), bone marrow (RPKM 482.7) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白 L30P 家族。它包含一个 N 末端基本区域亮氨酸拉链 (BZIP) 样结构域和 RNP 共识子基序 RNP2。在体外，BZIP 样结构域介导同源二聚化和与 DNA 和 RNA 的稳定结合，偏爱 28S rRNA 和 mRNA。该蛋白可以抑制 mRNA 的无细胞翻译，表明它在翻译装置中发挥调节作用。它位于细胞质中。该蛋白已被证明是全身性自身免疫性疾病患者的自身抗原，例如系统性红斑狼疮。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL7 基因产物(2)

mRNA	Protein	Name
NM_000971.4	NP_000962.2	60S ribosomal protein L7 isoform 1
NM_001363737.2	NP_001350666.1	60S ribosomal protein L7 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	8441630	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	8441630	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	8441630	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18274552	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
enables structural constituent of ribosome	IMP IMP: 通过突变表型推断	18697920	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in rRNA processing	IMP IMP: 通过突变表型推断	18697920	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: 通过突变表型推断	18697920	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cytosolic large ribosomal subunit	IDA IDA: 通过直接分析推断	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: 通过物理相互作用推断	25901680	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
is active in postsynaptic density	EXP EXP: 通过实验结果推断	21170055	GOA
is active in postsynaptic density	IDA IDA: 通过直接分析推断	21170055	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	18809582	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL7 蛋白结构

Ribosomal_L30_N

Ribosomal_L30

0
100
200
248 a.a.

蛋白主名

其他名称

60S ribosomal protein L7

large ribosomal subunit protein uL30

RPL7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPL7	P18124	IPO5	Homo sapiens	O00410	Pull Down	20828572
种属内	RPL7	P18124	IPO5	Homo sapiens	O00410	Biophysical	20828572
种属内	RPL7	P18124	IPO5	Homo sapiens	O00410	Affinity Chrom	20828572

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12203	RPL7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12204	RPL7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RPL7	RGD	RGD:735169
Macaca mulatta	RPL7	VGNC	VGNC:99475
Mus musculus	RPL7	MGD	MGI:98073

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