2. Gene
  3. SEC62 - SEC62 homolog, preprotein translocation factor Gene

SEC62 - SEC62 homolog, preprotein translocation factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SEC62 同系物，前蛋白易位因子

种属: Homo sapiens

同用名: HTP1; TP-1; Dtrp1; TLOC1

基因 ID: 7095 | 基因类型: protein coding

关于 SEC62

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:169,966,807-169,998,373 (from NCBI)

This gene has 10 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in thyroid (RPKM 46.4), brain (RPKM 36.2) and 25 other tissues.

功能概要

Sec61 复合体是内质网 (ER) 膜蛋白质易位装置的核心组成部分。发现由该基因编码的蛋白质和 SEC63 蛋白质与无核糖体的 SEC61 复合物相关。据推测，Sec61-Sec62-Sec63 可能会进行翻译后蛋白质易位到 ER 中。 Sec61-Sec62-Sec63 复合物也可能执行受遍在蛋白-蛋白酶体依赖性降解途径影响的 ER 蛋白的反向转运。编码的蛋白质是位于粗糙 ER 中的完整膜蛋白。[RefSeq 提供，2008 年 7 月]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

SEC62 基因产物(1)

mRNA Protein Name
NM_003262.4 NP_003253.1 translocation protein SEC62
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
33961781 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within post-translational protein targeting to endoplasmic reticulum membrane IMP
IMP: 通过突变表型推断
22375059 GOA
involved in post-translational protein targeting to membrane, translocation IMP
IMP: 通过突变表型推断
29719251 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
22375059 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEC62 蛋白结构

Sec62

Sec62: Translocation protein Sec62 (87 - 307)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

translocation protein SEC62

SEC62 preprotein translocation factor

SEC62 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SEC62 Q99442 GABARAP Homo sapiens O95166
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease

Isolated Polycystic Liver Disease

Pcld

Congenital Cystic Liver Disease

Congenital Hepatic Cyst

Fibrocystic Liver Disease

Isolated Autosomal Dominant Polycystic Liver Disease

Adpcld

Liver Disease, Polycystic

Multiple Cysts Of Liver

Pld - [Polycystic Liver Disease]

Polycystic Liver Disorder

Polycystic Liver

Congenital Polycystic Disease Of Liver

Congenital Polycystic Liver Disease
Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I

Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

Hsan1e

Hsan1

Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

Hsn1e

Hsnie

Hereditary Sensory Neuropathy Type Ie

Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

Hereditary Sensory And Autonomic Neuropathy Type Ie

Hereditary Sensory And Autonomic Neuropathy Type 1e

Hereditary Sensory Neuropathy With Hearing Loss And Dementia

Dnmt1-Complex Disorder

Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

Hsn Ie

Hereditary Sensory Autonomic Neuropathy, Type 1

Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12624 SEC62 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SEC62 VGNC VGNC:56236
Felis catus SEC62 VGNC VGNC:102838
Mus musculus SEC62 MGD MGI:1916526
Macaca mulatta SEC62 VGNC VGNC:84085
Rattus norvegicus SEC62 RGD RGD:1308862
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