2. 重组蛋白
  3. Receptor Proteins
  4. GABARAP 蛋白, Human (His-MBP)

GABARAP 蛋白, Human (His-MBP)

目录号: HY-P76942
产品使用指南

GABARAP 蛋白对于调节 TIAM1 的泛素化和降解至关重要，TIAM1 是一种鸟苷酸交换因子 (GEF)，参与 RAC1 激活和下游信号传导。D6/7 E3 泛素连接酶复合物（其中 GABARAP 是关键成分）有助于多种生物过程，包括细胞骨架组织、细胞迁移、增殖和凋亡。GABARAP 蛋白, Human (His-MBP) 是重组的 GABARAP 蛋白，由 E. coli 表达，带有 N-His, N-MBP 标签。GABARAP 蛋白, Human (His-MBP) 全长 117 个氨基酸，分子量为 49-58 kDa。

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描述

GABARAP Protein is essential for regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) involved in RAC1 activation and downstream signaling. The D6/7 E3 ubiquitin ligase complex, where GABARAP is a key component, contributes to diverse biological processes, including cytoskeletal organization, cell migration, proliferation, and apoptosis. GABARAP Protein, Human (His-MBP) is the recombinant human-derived GABARAP protein, expressed by E. coli , with N-His, N-MBP labeled tag. The total length of GABARAP Protein, Human (His-MBP) is 117 a.a., with molecular weight of 49-58 kDa.
研究背景

D6/7 E3 泛素连接酶复合物负责调节 TIAM1 的泛素化和降解过程，TIAM1 是一种鸟苷酸交换因子 (GEF)，可激活 RAC1 和下游信号转导。该复合物在多种生物过程中发挥作用，包括细胞骨架的组织、细胞迁移、增殖和凋亡。
种属

Human
表达系统

E. coli
标签

N-His;N-MBP
蛋白编号

O95166 (M1-L117)
基因 ID
蛋白结构
N-term
His-MBP
GABARAP (M1-L117)
Accession # O95166
C-term
同用名
GABA(A) Receptor-Associated Protein; HCG1987397 Isoform CRA_b
分子量

49-58 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GABARAP Protein, Human (His-MBP) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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