GAD2/GAD65 蛋白, Mouse (sf9)

GAD2/GAD65 Protein is a key enzyme in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). Meanwhile, GAD2 also has glutamate binding activity, glutamate decarboxylase activity, and pyridoxal phosphate binding activity. GAD2 is expressed in several structures, including the genitourinary system, the gastrointestinal nervous system, and sensory organs. It can be used to study epilepsy and type 1 diabetes. GAD2/GAD65 Protein, Mouse (sf9) is the recombinant mouse-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with tag free. The total length of GAD2/GAD65 Protein, Mouse (sf9) is 585 a.a., with molecular weight of ~58 kDa.

谷氨酸脱羧酶 2 (GAD2) 是神经递质代谢中的关键酶，特别是催化 γ-氨基丁酸 (GABA) 的产生。GABA是中枢神经系统中重要的抑制性神经递质，在调节神经元兴奋性、维持大脑兴奋与抑制之间的平衡方面发挥着关键作用。作为 GABA 合成的催化剂，GAD2 在调节神经传递和影响各种生理过程中发挥着重要作用，凸显了其在神经系统内复杂的神经信号网络中的重要性。同时，GAD2还具有谷氨酸结合活性、谷氨酸脱羧酶活性和磷酸吡哆醛结合活性。GAD2 在多种结构中表达，包括泌尿生殖系统、胃肠神经系统和感觉器官。此外，GAD2 可用于研究癫痫和 1 型糖尿病^[1]。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

Sf9 insect cells

Tag Free

Q548L4 (N-G&P, M1-L585)

14417  [NCBI]

Approximately 58 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, 10% Glycerol, 3 mM DTT, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.