Galectin-1/LGALS1 蛋白, Mouse

Galectin-1/LGALS1 protein is a β-galactoside-binding lectin that regulates apoptosis, cell proliferation, and differentiation by inhibiting CD45 protein phosphatase.It prevents Lyn kinase dephosphorylation, induces T cell apoptosis as a homodimer, and interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45.Galectin-1/LGALS1 Protein, Mouse is the recombinant mouse-derived Galectin-1/LGALS1 protein, expressed by E.coli , with tag free.

Galectin-1/LGALS1 蛋白作为一种多功能凝集素，对 β-半乳糖苷和多种复杂碳水化合物具有高亲和力。其关键作用延伸至细胞凋亡、细胞增殖和细胞分化的调节。值得注意的是，Galectin-1/LGALS1 作为 CD45 蛋白磷酸酶活性的抑制剂，从而防止 Lyn 激酶的去磷酸化。此外，它还是 T 细胞凋亡的有效诱导剂，并以同二聚体形式存在。该蛋白参与多种相互作用，结合 LGALS3BP 并与细胞表面蛋白（如 CD2、CD3、CD4、CD6、CD7、CD43、ALCAM 和 CD45）相互作用。Galectin-1/LGALS1 还通过聚-N-乙酰基乳糖胺结合与层粘连蛋白形成关联，并与 SUSD2 相互作用。与货物受体 TMED10 发生值得注意的相互作用，促进从细胞质易位到内质网-高尔基中间室 (ERGIC) 和随后的分泌。

1. Measured by its ability to agglutinate human red blood cells. The ED₅₀ for this effect is typically 6-60 μg/mL.
2. Measured in a cell proliferation assay using HUVEC cells. The ED₅₀ for this effect is 1.105 μg/mL, corresponding to a specific activity is 904.98 units/mg.

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  Measured in a cell proliferation assay using HUVEC cells. The ED₅₀ this effect is 1.105 μg/mL, corresponding to a specific activity is 904.98 units/mg.

Mouse

E. coli

Tag Free

P16045 (M1-E135)

16852  [NCBI]

MACGLVASNLNLKPGECLKVRGEVASDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNTKEDGTWGTEHREPAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE

Approximately 15 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, 100 mM β-Lactose, pH 7.4. (Normally trehalose is added as protectant before lyophilization. ) or 20 mM PB, 150 mM NaCl, 100 mM β-lactose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.