2. 重组蛋白
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily Neurotrophic Factors
  5. Growth Differentiation Factor GDNF family
  6. Growth Differentiation Factor 15 (GDF-15)
  7. GDF-15 蛋白, Cynomolgus (His)

GDF-15 蛋白, Cynomolgus (His)

目录号: HY-P700866
产品使用指南

GDF-15 蛋白是食物摄入和能量平衡的关键调节剂，与其受体 GFRAL 结合，激活脑干中的神经元，并形成应激期间进食反应的“紧急回路”。此外，GDF-15 抑制肝细胞上的生长激素信号传导，以二硫键连接的同二聚体形式存在。它与 GFRAL 相互作用，充当配体，通过 RET 介导 GDF15 内化和细胞信号传导。GDF-15 蛋白, Cynomolgus (His) 是重组的 GDF-15 蛋白，由 E. coli 表达，带有 N-His 标签。GDF-15 蛋白, Cynomolgus (His) 全长 116 个氨基酸，分子量为 15-18 kDa。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

GDF-15 Protein, a key regulator of food intake and energy balance, binds to its receptor GFRAL, activating neurons in the brainstem and forming an 'emergency circuit' for feeding responses during stress. Additionally, GDF-15 inhibits growth hormone signaling on hepatocytes, existing as a disulfide-linked homodimer. Interacting with GFRAL, it acts as a ligand, mediating GDF15 internalization and cellular signaling through RET. GDF-15 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived GDF-15 protein, expressed by E. coli, with N-His labeled tag. The total length of GDF-15 Protein, Cynomolgus (His) is 116 a.a., with molecular weight of 15-18 kDa.
研究背景

GDF-15 蛋白是食物摄入、能量消耗和体重的关键调节剂，以应对代谢和毒素引起的压力。它通过与其受体 GFRAL 结合并激活脑干后区和孤束核中表达 GFRAL 的神经元来发挥作用。这种激活随后导致臂旁核和中央杏仁核内神经元的激活，这些神经元构成“紧急回路”的一部分，负责在压力条件下形成进食反应。此外，GDF-15 蛋白可抑制肝细胞上的生长激素信号传导，并以二硫键连接的同型二聚体形式存在。它还与 GFRAL 相互作用，作为配体通过与 RET 的相互作用介导 GDF15 内化和细胞信号传导。
种属

Cynomolgus
表达系统

E. coli
标签

N-His
蛋白编号

G7PWZ3 (R193-V308)
基因 ID
蛋白结构
N-term
His
GDF-15 (R193-V308)
Accession # G7PWZ3
C-term
同用名
GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β
分子量

15-18 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GDF-15 Protein, Cynomolgus (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
GDF-15 Protein, Cynomolgus (His)
目录号：
HY-P700866
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z