2. 重组蛋白
  3. Cytokines and Growth Factors Biotinylated Proteins
  4. TGF-beta Superfamily Neurotrophic Factors
  5. Growth Differentiation Factor GDNF family
  6. Growth Differentiation Factor 15 (GDF-15)
  7. GDF-15 蛋白, Human (Biotinylated, His-Avi)

GDF-15 蛋白, Human (Biotinylated, His-Avi)

目录号: HY-P700665
产品使用指南 技术支持

GDF-15 蛋白对于调节食物摄入、能量消耗和体重以应对代谢和毒素引起的压力至关重要。它与其受体 GFRAL 结合并激活脑干中表达 GFRAL 的神经元。GDF-15 蛋白, Human (Biotinylated, His-Avi) 是重组的 GDF-15 蛋白，由 E. coli 表达，带有 C-Avi, N-His 标签。

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SPR 检测服务   重组蛋白定制服务

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

The GDF-15 protein is critical for regulating food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stress. It binds to its receptor GFRAL and activates GFRAL-expressing neurons in the brainstem. GDF-15 Protein, Human (Biotinylated, His-Avi) is the recombinant human-derived GDF-15 protein, expressed by E. coli , with C-Avi, N-His labeled tag.
研究背景

GDF-15 蛋白在调节食物摄入、能量消耗和体重以应对代谢和毒素引起的压力方面发挥着关键作用。它通过与其受体 GFRAL 结合并激活脑干后区和孤束核中表达 GFRAL 的神经元来发挥作用。这种激活随后触发臂旁核和杏仁核中央神经元的激活，形成“紧急回路”的一部分，参与在压力条件下塑造进食反应。此外，GDF-15 蛋白还可抑制肝细胞上的生长激素信号传导。它以同二聚体形式存在，并与 GFRAL 相互作用，作为配体通过与 RET 相互作用介导 GDF15 内化和细胞信号传导。
种属

Human
表达系统

E. coli
标签

N-His;N-Avi
蛋白编号

Q99988 (A197-I308)
基因 ID
蛋白结构
N-term
His-Avi
GDF-15 (A197-I308)
Accession # Q99988
C-term
同用名
GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β
分子量

15.19 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GDF-15 Protein, Human (Biotinylated, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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