GIPR 蛋白, Human (HEK293, His)

GIPR protein, a receptor for glucose-dependent insulinotropic polypeptide (GIP), operates through G proteins that activate adenylyl cyclase. Its capacity for homodimer and heterodimer formation with GLP1R implies potential interactions between receptors linked to incretin hormones. GIPR Protein, Human (HEK293, His) is the recombinant human-derived GIPR, expressed by HEK293 , with C-10*His labeled tag. The total length of GIPR Protein, Human (HEK293, His) is 117 a.a..

GIPR 蛋白作为葡萄糖依赖性促胰岛素多肽 (GIP) 的受体发挥作用。其活性由 G 蛋白介导，特别是那些激活腺苷酸环化酶的蛋白。值得注意的是，GIPR 有可能与 GLP1R 形成同二聚体和异二聚体，这表明与肠促胰岛素激素相关的受体之间可能存在相互作用。

Measured by its binding ability in a functional ELISA. Immobilized Human GIPR at 2 μg/mL can bind Anti-GIPR recombinant antibody. The ED₅₀ is 19.68 ng/mL.

Human

HEK293

C-10*His

P48546-1 (R22-Q138)

2696

RAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQ

Approximately 22-28 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.