2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Neurotrophic Factors
  5. Glia maturation factor beta/GMFB 蛋白, Human (His)

Glia maturation factor beta/GMFB 蛋白, Human (His)

目录号: HY-P70387
产品使用指南

胶质成熟因子β（GMFB）蛋白是促进脑细胞分化、刺激神经再生和抑制肿瘤细胞增殖的关键调节因子。磷酸化，特别是由佛波酯诱导的磷酸化，增强其活性，表明响应外部信号的精细调节机制。Glia maturation factor beta/GMFB 蛋白, Human (His) 是重组的 神经胶质成熟因子 β/GMFB 蛋白，由 E. coli 表达，带有 C-6*His 标签。Glia maturation factor beta/GMFB 蛋白, Human (His) 全长 142 个氨基酸，分子量约为 ~18.0 kDa。

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描述

Glial maturation factor beta (GMFB) protein serves as a key regulator that promotes brain cell differentiation, stimulates nerve regeneration and inhibits tumor cell proliferation. Phosphorylation, particularly that induced by phorbol esters, enhances its activity, suggesting a finely regulated mechanism in response to external signals. Glia maturation factor beta/GMFB Protein, Human (His) is the recombinant human-derived Glia maturation factor beta/GMFB protein, expressed by E. coli , with C-6*His labeled tag. The total length of Glia maturation factor beta/GMFB Protein, Human (His) is 142 a.a., with molecular weight of ~18.0 kDa.
研究背景

神经胶质成熟因子β (GMFB) 蛋白作为多种细胞过程的关键调节因子，促进脑细胞分化，刺激神经再生，同时抑制肿瘤细胞增殖。这种多功能蛋白质经历磷酸化，这是一种增强其活性的修饰，并且特别受佛波酯的刺激。GMFB 的磷酸化状态表明存在一种调节机制，可以根据外部信号微调其功能，可能在细胞信号级联中发挥至关重要的作用。GMFB 影响神经发育和肿瘤细胞增殖的双重能力凸显了其在基本生物过程中的多功能和复杂参与，表明其在调节细胞命运和功能中发挥重要作用的潜力。
种属

Human
表达系统

E. coli
标签

C-6*His
蛋白编号

P60983 (M1-H142)
基因 ID
蛋白结构
N-term
GMFB (M1-H142)
Accession # P60983
6*His
C-term
同用名
rHuGlia maturation factor beta/GMF-beta, His; Glia maturation factor beta; GMF-beta; GMFB
氨基酸序列

MSESLVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEWLREKLGFFH

分子量

Approximately 18.0 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Glia maturation factor beta/GMFB Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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