GMPR 蛋白, Human (HEK293, His)

GMP reductase 1 (GMPR1) catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. GMPR1 functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. GMPR1 contributes to non-shivering thermogenesis while promoting the progression of Alzheimer's disease. GMPR Protein, Human (HEK293, His) is the recombinant human-derived GMPR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMPR Protein, Human (HEK293, His) is 345 a.a., with molecular weight of ~40.0 kDa.

GMP 还原酶 1 (GMPR1) 催化 GMP 不可逆的 NADPH 依赖性脱氨基为 IMP。GMPR1 参与 G 核苷酸的碱基、核苷和核苷酸衍生物向 A 核苷酸的转化，并维持细胞内 A 和 G 核苷酸的平衡。
冷暴露可上调 GMPR1 的表达，表明 GMPR1 可能参与非寒颤产热过程。然而，在阿尔茨海默病中，GMPR 也会增加，IMP 可以转化为 AMP 和腺苷 A，而腺苷 A 可以与 A1/A2 受体结合 (对介导 Tau 磷酸化很重要)，导致阿尔兹海默的进展^[1][2]。

Human

HEK293

C-6*His

AAH08281.1 (M1-S345)

2766  [NCBI]

MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMNKHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFS

Approximately 40.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.