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  2. GMPR - guanosine monophosphate reductase Gene

GMPR - guanosine monophosphate reductase Gene

中文名称:鸟苷一磷酸还原酶

种属: Homo sapiens

同用名: GMPR1; GMPR 1

基因 ID: 2766 | 基因类型: protein coding

关于 GMPR

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:16,238,587-16,295,549 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 3 paralogues. Broad expression in prostate (RPKM 33.0), testis (RPKM 29.5) and 19 other tissues.

功能概要

该基因编码一种酶,该酶催化 GMP 向 IMP 的不可逆和 NADPH 依赖性还原脱氨作用。该蛋白质还在游离细胞内碱基和嘌呤核苷的再利用中发挥作用。[RefSeq 提供,2009 年 10 月]

This gene encodes an Enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]

GMPR 基因产物(1)

mRNA Protein Name
NM_006877.4 NP_006868.3 GMP reductase 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GMP reductase activity IDA
IDA: 通过直接分析推断
22332716 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
33961781 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GMPR 蛋白结构

IMPDH

IMPDH: IMP dehydrogenase / GMP reductase domain (9 - 341)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
蛋白主名 其他名称

GMP reductase 1

guanine monophosphate reductase

重组 GMPR 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70955 GMPR Protein, Human (HEK293, His) AAH08281.1 (M1-S345) ≥95%
HY-P75791 GMPR Protein, Human (His) P36959/NP_006868.3 (M1-S345) ≥95%

关联疾病

疾病名称 别名
Viral Gastritis
Cystathioninuria

Cystathionase Deficiency

Gamma-Cystathionase Deficiency

Cystathione Gamma-Lyase Deficiency Syndrome

Cystathionine Gamma-Lyase Deficiency Syndrome

CSTNU

Fumarase Deficiency

Fumaric Aciduria

FMRD

Fumarate Hydratase Deficiency

Deficiency, Fumarase

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus GMPR MGD MGI:1913605
Macaca mulatta GMPR VGNC VGNC:73082
Rattus norvegicus GMPR RGD RGD:70980
Felis catus GMPR VGNC VGNC:62612
Canis familiaris GMPR VGNC VGNC:41294
Bos taurus GMPR VGNC VGNC:29442
Others GMPR NCBI