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  3. GMPR2 - guanosine monophosphate reductase 2 Gene

GMPR2 - guanosine monophosphate reductase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟苷一磷酸还原酶 2

种属: Homo sapiens

同用名: GMPR 2

基因 ID: 51292 | 基因类型: protein coding

关于 GMPR2

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,232,622-24,239,242 (from NCBI)

This gene has 29 transcripts (splice variants), 1 gene allele, 187 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 24.5), kidney (RPKM 21.7) and 25 other tissues.

功能概要

该基因编码一种酶，该酶催化鸟苷一磷酸 (GMP) 不可逆和 NADPH 依赖性还原脱氨作用成为肌苷一磷酸 (IMP) 。该蛋白质还在游离细胞内碱基和嘌呤核苷的再利用中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 4 月]

This gene encodes an Enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GMPR2 基因产物(12)

mRNA Protein Name
NM_001002000.3 NP_001002000.1 GMP reductase 2 isoform 2
NM_001002001.3 NP_001002001.1 GMP reductase 2 isoform 2
NM_001002002.3 NP_001002002.1 GMP reductase 2 isoform 2
NM_001283021.2 NP_001269950.1 GMP reductase 2 isoform 3
NM_001283022.2 NP_001269951.1 GMP reductase 2 isoform 4
NM_001283023.2 NP_001269952.1 GMP reductase 2 isoform 5
NM_001351022.2 NP_001337951.1 GMP reductase 2 isoform 6
NM_001351023.2 NP_001337952.1 GMP reductase 2 isoform 6
NM_001351024.2 NP_001337953.1 GMP reductase 2 isoform 7
NM_001351025.2 NP_001337954.1 GMP reductase 2 isoform 7
NM_001351026.2 NP_001337955.1 GMP reductase 2 isoform 7
NM_016576.5 NP_057660.2 GMP reductase 2 isoform 1

GMPR2 蛋白结构

IMPDH

IMPDH: IMP dehydrogenase / GMP reductase domain (9 - 341)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
蛋白主名 其他名称

GMP reductase 2

guanosine 5'-monophosphate oxidoreductase 2

关联疾病

疾病名称 别名
Urethra Cancer

Cancer Of Urethra

Malignant Tumour Of Urethra

Malignant Urethral Neoplasm

Urethral Ca
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05527 GMPR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GMPR2 VGNC VGNC:41295
Mus musculus GMPR2 MGD MGI:1917903
Macaca mulatta GMPR2 VGNC VGNC:73083
Felis catus GMPR2 VGNC VGNC:62613
Rattus norvegicus GMPR2 RGD RGD:628875
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