envelope glycoprotein gp120 蛋白, HIV-1 (AAA44191, HEK293 , His)

envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope.Gp120 is essential for viral infection as it facilitates HIV entry into the host cell.gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus.envelope glycoprotein gp120 Protein, HIV-1 (AAA44191, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-10*His labeled tag.

包膜糖蛋白 gp120 (gp120) 是暴露在 HIV 包膜表面的糖蛋白。Gp120 对于病毒感染至关重要，因为它可以促进 HIV 进入宿主细胞，它在附着于特定细胞表面受体方面发挥着至关重要的作用。这些受体是 DC-SIGN、硫酸乙酰肝素蛋白聚糖以及与 CD4 受体的特异性相互作用，特别是在辅助 T 细胞上。gp120 还可能通过影响 T 细胞对病毒的免疫反应来促进病毒持久性和持续的 HIV 感染。在这个过程中可能涉及几种机制，gp120 与 T 细胞的 CD4 受体结合，促进病毒进入 CD4+ 细胞并消灭它们。Gp120 从病毒膜上脱落并在淋巴组织中大量积累。它可以诱导细胞凋亡，并通过抑制抗病毒 CTL 反应来严重改变对病毒的免疫反应，从而阻碍 HIV 的清除^[1]。

Virus

HEK293

C-10*His

AAA44191.1 (E30-R509)

/

EEKLWVTVYYGVPVWKEATTTLFCASDRKAYDTEVHNVWATHACVPTDPNPQEVELKNVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDLRNATNGNDTNTTSSSRGMVGGGEMKNCSFNITTNIRGKVQKEYALFYKLDIAPIDNNSNNRYRLISCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGKGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSANFADNAKVIIVQLNESVEINCTRPNNNTRKSIHIGPGRAFYTTGEIIGDIRQAHCNLSRAKWNDTLNKIVIKLREQFGNKTIVFKHSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWNVTEESNNTVENNTITLPCRIKQIINMWQEVGRAMYAPPIRGQIRCSSNITGLLLTRDGGPEDNKTEVFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKR

95-150 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.