2. 重组蛋白
  3. Receptor Proteins Biotinylated Proteins
  4. Growth Hormone R/GHR 蛋白, Human (Biotinylated, HEK293, His)

Growth Hormone R/GHR 蛋白, Human (Biotinylated, HEK293, His)

目录号: HY-P78869
产品使用指南

生长激素 R (GHR) 是垂体生长激素的受体，对于产后身体生长调节至关重要。与其配体结合可激活 JAK2/STAT5 通路，促进细胞内信号传导。可溶形式的 GHBP（生长激素结合蛋白）在血液中充当生长激素储存库。GHBP 可以调节或抑制生长激素信号传导，有助于复杂的生长过程调节。Growth Hormone R/GHR 蛋白, Human (Biotinylated, HEK293, His) 是重组的 生长激素 R/GHR 蛋白，由 HEK293 表达，带有 C-His 标签。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

Growth Hormone R (GHR) is the receptor for pituitary growth hormone, crucial in postnatal body growth regulation. Binding to its ligand activates the JAK2/STAT5 pathway, facilitating intracellular signaling. The soluble form, GHBP (Growth Hormone Binding Protein), acts as a growth hormone reservoir in the bloodstream. GHBP may modulate or inhibit growth hormone signaling, contributing to intricate growth process regulation. Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Growth Hormone R/GHR protein, expressed by HEK293 , with C-His labeled tag.
研究背景

生长激素R（GHR）作为垂体生长激素的受体，在调节产后身体生长中发挥着关键作用。与其配体结合后，GHR 激活 JAK2/STAT5 通路，促进细胞内信号级联反应。此外，该受体的可溶形式称为 GHBP（生长激素结合蛋白），可作为血液中生长激素的储存库。GHBP 还可能对生长激素信号传导发挥调节或抑制作用，有助于生长过程的复杂调节。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

P10912-1 (A27-Y264)
基因 ID
蛋白结构
N-term
GHR (A27-Y264)
Accession # P10912-1
His
C-term
同用名
GHR; GHBP; GH receptor
分子量

40-60 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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