Growth Hormone R/GHR 蛋白, Human (HEK293, hFc)

Growth Hormone R (GHR) is the receptor for pituitary growth hormone, crucial in postnatal body growth regulation. Binding to its ligand activates the JAK2/STAT5 pathway, facilitating intracellular signaling. The soluble form, GHBP (Growth Hormone Binding Protein), acts as a growth hormone reservoir in the bloodstream. GHBP may modulate or inhibit growth hormone signaling, contributing to intricate growth process regulation. Growth Hormone R/GHR Protein, Human (HEK293, hFc) is the recombinant human-derived Growth Hormone R/GHR protein, expressed by HEK293 , with C-hFc labeled tag.

生长激素R（GHR）作为垂体生长激素的受体，在调节产后身体生长中发挥着关键作用。与其配体结合后，GHR 激活 JAK2/STAT5 通路，促进细胞内信号级联反应。此外，该受体的可溶形式称为 GHBP（生长激素结合蛋白），可作为血液中生长激素的储存库。GHBP 还可能对生长激素信号传导发挥调节或抑制作用，有助于生长过程的复杂调节。

1.Measured by its binding ability in a functional ELISA. Immobilized GH1 at 1 μg/mL can bind human GHR and the EC₅₀ of human GHR protein is 7.006-11.72 ng/mL.
2.Measured by its ability to inhibit GH-induced proliferation of Nb2-11 rat lymphoma cells. The ED₅₀ for this effect is 0.52 ng/mL in the presence of 0.2 ng/mL GH, corresponding to a specific activity is 1.92×10⁶ units/mg.

Human

HEK293

C-hFc

P10912-1 (A27-Y264)

2690  [NCBI]

AILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFY

Approximately 66-95 kDa due to the glycosylation.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS, 6-8% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.