1. 重组蛋白
  2. Receptor Proteins
  3. Growth Hormone R/GHR 蛋白, Mouse (HEK293, His-Fc)

Growth Hormone R/GHR 蛋白, Mouse (HEK293, His-Fc)

目录号: HY-P73086
产品使用指南

生长激素R/GHR蛋白作为垂体生长激素的受体,在调节产后身体生长方面发挥着至关重要的作用。配体结合激活 JAK2/STAT5 通路,影响生长调节中的下游信号传导。Growth Hormone R/GHR 蛋白, Mouse (HEK293, His-Fc) 是重组的 生长激素 R/GHR 蛋白,由 HEK293 表达,带有 C-hFc, C-His 标签。

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描述

Growth hormone R/GHR protein, as a receptor for pituitary growth hormone, plays a crucial role in regulating postpartum body growth. Ligand binding activates the JAK2/STAT5 pathway, affecting downstream signaling in growth regulation. Growth Hormone R/GHR Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived Growth Hormone R/GHR protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

研究背景

生长激素R/GHR蛋白作为垂体生长激素的受体,在调节产后身体生长中发挥着至关重要的作用。配体结合后,它偶联并激活 JAK2/STAT5 通路,促进参与生长调节的下游信号传导事件。值得注意的是,该受体的可溶形式(称为 GHBP)充当血浆中生长激素的储存库,并具有调节或抑制 GH 信号传导的潜力,从而为生长过程的精细控制增加了一层复杂性。生长激素 R/GHR 在介导生长激素作用和调节其信号传导方面的双重作用凸显了其在控制出生后生长的复杂调节机制中的重要性。

种属

Mouse

表达系统

HEK293

标签

C-hFc;C-His

蛋白编号

P16882/NP_034414.2 (T25-Q273)

基因 ID
蛋白结构
N-term
Growth Hormone R/GHR (T25-Q273)
Accession # P16882/NP_034414.2
hFc-His
C-term
同用名
Growth hormone receptor; GH receptor GHBP; Ghr
氨基酸序列

MDLCQVFLTLALAVTSSTFSGSEATPATLGKASPVLQRINPSLGTSSSGKPRFTKCRSPELETFSCYWTEGDNPDLKTPGSIQLYYAKRESQRQAARIAHEWTQEWKECPDYVSAGKNSCYFNSSYTSIWIPYCIKLTTNGDLLDQKCFTVDEIVQPDPPIGLNWTLLNISLTGIRGDIQVSWQPPPNADVLKGWIILEYEIQYKEVNESKWKVMGPIWLTYCPVYSLRMDKEHEVRVRSRQRSFEKYSEFSEVLRVIFPQTNILEACEEDIQ

分子量

70-80 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Growth Hormone R/GHR Protein, Mouse (HEK293, His-Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Growth Hormone R/GHR Protein, Mouse (HEK293, His-Fc)
目录号:
HY-P73086
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