2. Gene
  3. Ghr - growth hormone receptor Gene

Ghr - growth hormone receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: GHBP; GHR/BP

基因 ID: 14600 | 基因类型: protein coding

关于 Ghr

功能概要

Enables growth hormone receptor activity and peptide hormone binding activity. Involved in growth hormone receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of growth. Acts upstream of or within taurine metabolic process. Located in nucleus and plasma membrane. Is extrinsic component of membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Used to study Laron syndrome. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghr 基因产物(3)

mRNA Protein Name
NM_001048178.2 NP_001041643.1 growth hormone receptor isoform 2 precursor
NM_001286370.1 NP_001273299.1 growth hormone receptor isoform 1 precursor
NM_010284.3 NP_034414.2 growth hormone receptor isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth hormone receptor activity IDA
IDA: 通过直接分析推断
6303755 MGI
enables peptide hormone binding IPI
IPI: 通过物理相互作用推断
10556780 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8702683 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in growth hormone receptor signaling pathway IDA
IDA: 通过直接分析推断
8702683 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
8702683 MGI
involved in regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
18648510 MGI
acts upstream of positive effect taurine metabolic process IMP
IMP: 通过突变表型推断
18648510 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
11834450 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9144201 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
9144201 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

growth hormone receptor

GH receptor

Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein)

growth hormone receptor/binding protein, high molecular weight

growth hormone receptor/binding protein, low molecular weight

somatotropin r

重组 Ghr 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70850 Growth Hormone R/GHR Protein, Mouse (HEK293, Fc) Q3UP14 (M1-Q273) ≥95%
HY-P73086 Growth Hormone R/GHR Protein, Mouse (HEK293, His-Fc) P16882/NP_034414.2 (T25-Q273) ≥95%
HY-P73087 Growth Hormone R/GHR Protein, Mouse (HEK293, His) P16882/NP_034414.2 (T25-Q273) ≥95%

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-164419A Atesidorsen sodium Inhibitor 91.84% Phase 2
HY-153485 Cimdelirsen Inhibitor / Phase 2
HY-153485A Cimdelirsen sodium Inhibitor / Phase 2
HY-164419 Atesidorsen Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-159697 ISIS 532401 / 否
HY-159697A ISIS 532401 sodium / 否
HY-P10283 S1H Antagonist / 否
HY-RS05412 GHR Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ghr NCBI NCBI:2690
Rattus norvegicus Ghr NCBI NCBI:25235
Macaca mulatta Ghr NCBI NCBI:697986
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