2. Metabolic Enzyme/Protease Epigenetics
  3. GHR Small Interfering RNA (siRNA)
  4. Cimdelirsen sodium

Cimdelirsen sodium  (Synonyms: ISIS 766720 sodium; IONIS-GHR-LRx sodium)

目录号: HY-153485A
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摩尔计算器

Cimdelirsen (sodium) 是一种肝脏靶向的反义寡核苷酸，减少生长激素受体(GHr)的合成，从而抑制生长激素(GH)高分泌的有害影响，降低肢端肥大症患者循环胰岛素样生长因子-1 (IGF-1)的水平。

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DNA, d([2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rC-sp-T-sp-T-sp-T-sp-G-sp-G-sp-G-sp-T-sp-G-sp-A-sp-A-sp-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt (1:20)

Cimdelirsen sodium Chemical Structure

CAS No. : 2131025-83-5

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Cimdelirsen sodium 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

分子量

9128.16

Formula

C296H415N83Na20O152P20S15
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cimdelirsen sodium 相关分类

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Keywords:

Cimdelirsen2131025-83-5ISIS 766720IONIS-GHR-LRxISIS766720ISIS-766720GHRSmall Interfering RNA (siRNA)Growth Hormone ReceptorSomatotropin ReceptorGrowth Hormone Binding Protein (GHBP)Inhibitorinhibitorinhibit

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