2. Gene
  3. Ghr - growth hormone receptor Gene

Ghr - growth hormone receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: GHR/BP

基因 ID: 25235 | 基因类型: protein coding

关于 Ghr

功能概要

Enables SH2 domain binding activity; Enzyme binding activity; and growth hormone receptor activity. Involved in several processes, including activation of Janus kinase activity; cellular response to hormone stimulus; and receptor signaling pathway via JAK-STAT. Located in several cellular components, including extracellular space; mitochondrion; and neuronal cell body. Biomarker of congenital hypothyroidism; muscular atrophy; osteopetrosis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghr 基因产物(1)

mRNA Protein Name
NM_017094.2 NP_058790.1 growth hormone receptor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH2 domain binding IDA
IDA: 通过直接分析推断
12586763 RGD
enables SH2 domain binding IMP
IMP: 通过突变表型推断
10976913 RGD
enables SH2 domain binding IPI
IPI: 通过物理相互作用推断
10976913 RGD
enables growth hormone receptor activity IDA
IDA: 通过直接分析推断
11244571 RGD
enables protein kinase binding IDA
IDA: 通过直接分析推断
8063815 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
11244571 RGD
enables protein phosphatase binding IMP
IMP: 通过突变表型推断
10976913 RGD
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
10976913 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of Janus kinase activity IDA
IDA: 通过直接分析推断
11244571 RGD
involved in cartilage development involved in endochondral bone morphogenesis IEP
IEP: 通过表达模式推断
15749813 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
8063815 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
18040895 RGD
involved in growth hormone receptor signaling pathway IDA
IDA: 通过直接分析推断
8063815 RGD
involved in hormone-mediated signaling pathway IDA
IDA: 通过直接分析推断
11064147 RGD
acts upstream of positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
8063815 RGD
involved in positive regulation of cell differentiation IEP
IEP: 通过表达模式推断
12162495 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
11064147 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
10976913 RGD
involved in regulation of response to nutrient levels IMP
IMP: 通过突变表型推断
17258692 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
12654216 RGD
involved in response to food IEP
IEP: 通过表达模式推断
17634149 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
12162495 RGD
involved in response to gravity IEP
IEP: 通过表达模式推断
14638460 RGD
involved in response to growth hormone IEP
IEP: 通过表达模式推断
10987684 RGD
involved in response to hormone IEP
IEP: 通过表达模式推断
12162495 RGD
involved in response to interleukin-1 IEP
IEP: 通过表达模式推断
14518239 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
15334695 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
11126270 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
17258692 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

growth hormone receptor

GH receptor

growth hormone receptor variant d5-6

growth hormone receptor/binding protein

somatotropin receptor

重组 Ghr 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73088 Growth Hormone R/GHR Protein, Rat (HEK293, Fc) P16310-1 (F19-R265) ≥95%
HY-P73089 Growth Hormone R/GHR Protein, Rat (HEK293, His) P16310-1 (F19-R265) ≥95%

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-164419A Atesidorsen sodium Inhibitor 98.58% Phase 2
HY-153485 Cimdelirsen Inhibitor / Phase 2
HY-153485A Cimdelirsen sodium Inhibitor / Phase 2
HY-164419 Atesidorsen Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10283 S1H Antagonist 99.29% 否
HY-159697 ISIS 532401 / 否
HY-159697A ISIS 532401 sodium / 否
HY-RS05412 GHR Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ghr NCBI NCBI:2690
Mus musculus Ghr NCBI NCBI:14600
Macaca mulatta Ghr NCBI NCBI:697986
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