Growth Hormone R/GHR 蛋白, Rat (HEK293, His)

Growth Hormone R/GHR Protein, a receptor for pituitary growth hormone, regulates postnatal body growth by activating the JAK2/STAT5 pathway upon ligand binding.Its soluble form, GHBP, acts as a plasma reservoir for growth hormone and potentially modulates or inhibits GH signaling.Growth Hormone R/GHR Protein, Rat (HEK293, His) is the recombinant rat-derived Growth Hormone R/GHR protein, expressed by HEK293 , with C-His labeled tag.

生长激素 R (GHR) 蛋白作为垂体生长激素的受体，在调节产后身体生长中发挥着至关重要的作用。与其配体结合后，GHR 偶联并激活 JAK2/STAT5 信号通路。此外，可溶形式的 GHR，称为 GHBP（生长激素结合蛋白），可作为血浆中生长激素的储存库，并可充当生长激素信号传导的调节剂或抑制剂。GHR 和生长激素之间的动态相互作用强调了其在与身体生长相关的生理过程的复杂调节中的关键作用。

Measured by its ability to inhibit GH-induced proliferation of Nb2-11 rat lymphoma cells. The ED₅₀ of this effect is 0.5495 ng/mL in the presence of 0.2 ng/mL GH, corresponding to a specific activity is 1.8198×10⁶ units/mg.

Rat

HEK293

C-His

P16310-1 (F19-R265)

25235  [NCBI]

FPGSGATPATLGKASPVLQRINPSLRESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECPDYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLLNISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLYSLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEDFR

35-45 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.