Growth Hormone R/GHR 蛋白, Mouse (HEK293, His)

Growth hormone R/GHR protein, as a receptor for pituitary growth hormone, plays a crucial role in regulating postpartum body growth. Ligand binding activates the JAK2/STAT5 pathway, affecting downstream signaling in growth regulation. Growth Hormone R/GHR Protein, Mouse (HEK293, His) is the recombinant mouse-derived Growth Hormone R/GHR protein, expressed by HEK293 , with C-His labeled tag. The total length of Growth Hormone R/GHR Protein, Mouse (HEK293, His) is 249 a.a., with molecular weight of 40-45 kDa.

生长激素R/GHR蛋白作为垂体生长激素的受体，在调节产后身体生长中发挥着至关重要的作用。配体结合后，它偶联并激活 JAK2/STAT5 通路，促进参与生长调节的下游信号传导事件。值得注意的是，该受体的可溶形式（称为 GHBP）充当血浆中生长激素的储存库，并具有调节或抑制 GH 信号传导的潜力，从而为生长过程的精细控制增加了一层复杂性。生长激素 R/GHR 在介导生长激素作用和调节其信号传导方面的双重作用凸显了其在控制出生后生长的复杂调节机制中的重要性。

Measured by its ability to inhibit GH-induced proliferation of Nb2-11 rat lymphoma cells. The ED₅₀ of this effect is 1.455 ng/mL in the presence of 0.2 ng/mL GH, corresponding to a specific activity is 6.87×10⁵ units/mg.

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  Measured by its ability to inhibit GH-induced proliferation of Nb2-11 rat lymphoma cells. The ED₅₀ of this effect is 1.455 ng/mL in the presence of 0.2 ng/mL GH, corresponding to a specific activity is 6.87×10⁵ units/mg.

Mouse

HEK293

C-His

P16882/NP_034414.2 (T25-Q273)

14600  [NCBI]

TPATLGKASPVLQRINPSLGTSSSGKPRFTKCRSPELETFSCYWTEGDNPDLKTPGSIQLYYAKRESQRQAARIAHEWTQEWKECPDYVSAGKNSCYFNSSYTSIWIPYCIKLTTNGDLLDQKCFTVDEIVQPDPPIGLNWTLLNISLTGIRGDIQVSWQPPPNADVLKGWIILEYEIQYKEVNESKWKVMGPIWLTYCPVYSLRMDKEHEVRVRSRQRSFEKYSEFSEVLRVIFPQTNILEACEEDIQ

40-45 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.