GSTA1 蛋白, Human (HEK293, His, solution)

The GSTA1 protein catalyzes the attack of glutathione on various compounds, forming conjugates of PGA2 and PGJ2. It also converts AD into D4-androstene-3,17-dione, contributing to hormone biosynthesis. Additionally, it participates in the metabolism of oxidized linoleic acid through its peroxidase activity against 13-HPODE. GSTA1 Protein, Human (HEK293, His, solution) is the recombinant human-derived GSTA1 protein, expressed by HEK293 , with C-His labeled tag. The total length of GSTA1 Protein, Human (HEK293, His, solution) is 222 a.a., with molecular weight of ~26 kDa.

GSTA1 蛋白充当谷胱甘肽 S-转移酶，催化谷胱甘肽的硫原子对广谱外源和内源化合物的亲电基团进行亲核攻击（可能）。这种酶活性包括前列腺素 A2 (PGA2) 和前列腺素 J2 (PGJ2) 的谷胱甘肽缀合物的形成。此外，GSTA1 通过催化 D5-雄甾烯-3,17-二酮 (AD) 异构化为 D4-雄甾烯-3,17-二酮，在激素生物合成中发挥作用。值得注意的是，其谷胱甘肽依赖性过氧化物酶活性延伸至氧化亚油酸的代谢，特别针对脂肪酸氢过氧化物 (13S)-氢过氧-(9Z,11E)-十八碳二烯酸酯/13-HPODE。GSTA1 的多种酶功能强调了它参与重要的细胞过程，从解毒反应到激素生物合成和氧化脂质的代谢。

Human

HEK293

C-His

P08263 (M1-F222)

2938  [NCBI]

MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF

Approximately 26 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.