GSTA1 - glutathione S-transferase alpha 1 Gene

中文名称：谷胱甘肽 S-转移酶 α 1

种属: Homo sapiens

同用名: GST2; GTH1; GSTA1-1; GST-epsilon

基因 ID: 2938 | 基因类型: protein coding

关于 GSTA1

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,791,371-52,803,816 (from NCBI)

This gene has 3 transcripts (splice variants), 129 orthologues and 11 paralogues. Biased expression in liver (RPKM 342.4), kidney (RPKM 288.3) and 6 other tissues.

功能概要

该基因编码酶家族的一个成员，这些酶的功能是将谷胱甘肽添加到目标亲电子化合物中，包括致癌物、治疗药物、环境毒素和氧化应激产物。该作用是这些化合物解毒的重要步骤。该酶亚家族在保护细胞免受活性氧和过氧化产物的影响方面具有特殊作用。该基因的多态性影响个体代谢不同药物的能力。该基因位于 6 号染色体上的一组相似基因和假基因中。可变剪接导致多个转录本变异。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of a family of Enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of Enzymes has a particular role in protecting cells from Reactive Oxygen Species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GSTA1 基因产物(2)

mRNA	Protein	Name
NM_001319059.2	NP_001305988.1	glutathione S-transferase A1 isoform 2
NM_145740.5	NP_665683.1	glutathione S-transferase A1 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables fatty acid binding	IPI IPI: 通过物理相互作用推断	16624487	GOA
enables glutathione peroxidase activity	IDA IDA: 通过直接分析推断	16624487	GOA
enables glutathione transferase activity	IDA IDA: 通过直接分析推断	9084911	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA
enables steroid delta-isomerase activity	IDA IDA: 通过直接分析推断	11152686	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epithelial cell differentiation	IEP IEP: 通过表达模式推断	21492153	GOA
involved in glutathione derivative biosynthetic process	IDA IDA: 通过直接分析推断	9084911	GOA
acts upstream of or within glutathione metabolic process	IDA IDA: 通过直接分析推断	11851347	GOA
involved in glutathione metabolic process	IDA IDA: 通过直接分析推断	20606271	GOA
involved in linoleic acid metabolic process	IDA IDA: 通过直接分析推断	16624487	GOA
involved in prostaglandin metabolic process	IDA IDA: 通过直接分析推断	9084911	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSTA1 蛋白结构

GST_N

GST_C

0
100
200
222 a.a.

蛋白主名

其他名称

glutathione S-transferase A1

13-hydroperoxyoctadecadienoate peroxidase

重组 GSTA1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75153	GSTA1 Protein, Human (HEK293, His, solution)	P08263 (M1-F222)	≥95%

关联疾病

疾病名称

别名

Ovarian Endodermal Sinus Tumor

Endodermal Sinus Tumor Of Ovary	Ovarian Yolk Sac Tumor
Endodermal Sinus Tumour Of Ovary	Ovarian Endodermal Sinus Tumour
Ovarian Yolk Sac Tumour

Ovarian Primitive Germ Cell Tumor

Hemorrhagic Cystitis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N1963	Curzerene		98.00%	否
HY-RS16237	Gsta1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-N14116	Garlic oil	Inducer	/	否
HY-RS05872	GSTA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	GSTA1	RGD	RGD:2753
Others	GSTA1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GSTA1 - glutathione S-transferase alpha 1 Gene

关于 GSTA1

功能概要

GSTA1 基因产物(2)

GSTA1 蛋白结构

重组 GSTA1 蛋白

关联疾病

直系同源

热门区域

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GSTA1 - glutathione S-transferase alpha 1 Gene

关于 GSTA1

功能概要

GSTA1 基因产物(2)

GSTA1 蛋白结构

重组 GSTA1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z