HA1/Hemagglutinin 蛋白, Influenza B (ACO05957, HEK293, His)

Hemagglutinin (HA) is a class I viral fusion protein which is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. HA binds to sialic acid-containing receptors on the cell surface to bring about the attachment of the virus particle to the cell. The attachment of HA induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. HA plays a major role in the determination of host range restriction and virulence. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide and forming fusion pore. Several HA trimers are required to form a competent fusion pore^[1][2]. HA/Hemagglutinin Protein, Influenza B (ACO05957, 362a.a, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

血凝素 (HA) 是一类病毒融合蛋白，通过介导内吞病毒颗粒的膜与内体膜的融合，使病毒渗透到细胞质中。HA 与细胞表面含唾液酸的受体结合，使病毒颗粒附着在细胞上，并在决定宿主范围限制和毒力方面起着重要作用。

Virus

HEK293

C-His

ACO05957 (D16-R362)

/

55-60 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.