HAAO 蛋白, Rat (His)

HAAO Protein, an enzyme, is involved in the metabolism of tryptophan and the production of quinolinic acid. Dysregulation of HAAO Protein has been associated with neurodegenerative diseases and psychiatric disorders. HAAO Protein, Rat (His) is the recombinant rat-derived HAAO protein, expressed by E. coli , with N-His labeled tag. The total length of HAAO Protein, Rat (His) is 286 a.a., with molecular weight of ~34.8 KDa.

HAAO 蛋白通过催化 3-羟基邻氨基苯甲酸的氧化开环，导致 2-氨基-3-羧基粘康酸半醛的形成，在生化途径中发挥着至关重要的作用。然后，这种半醛化合物经历自发环化过程，最终产生喹啉酸盐。

Measured by its ability to inhibit the proliferation of PANC-1 Cells. The ED₅₀ for this effect is 0.106 μg/mL. Corresponding to a specific activity is 9.434×10³ Unit/mg.

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  Measured by its ability to inhibit the proliferation of PANC-1 Cells. The ED₅₀ for this effect is 0.106 μg/mL. Corresponding to a specific activity is 9.434×10³ Unit/mg.

Rat

E. coli

N-His

P46953 (M1-G286)

56823  [NCBI]

MERCVRVKSWVEENRASFQPPVCNKLMHREQLKIMFVGGPNTRKDYHIEEGEEVFYQLEGDMVLRVLEQGEHRDVVIRQGEIFLLPARVPHSPQRFANTMGLVIERRRMETELDGLRYYVGDTEDVLFEKWFHCKDLGTQLAPIIQEFFHSEQYRTGKPNPDQLLKEPPFPLSTRSVMEPMSLKAWLESHSRELQAGTSLSLFGDSYETQVIAHGQGSSKGPRQDVDVWLWQLEGSSKVTMGGQCVALAPDDSLLVPAGFSYMWERAQGSVALSVTQDPACKKPLG

Approximately 34.8 kDa.

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  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.