HACE1 蛋白, Human (His)

The HACE1 protein is an E3 ubiquitin protein ligase that regulates Golgi membrane fusion and small GTPases. HACE1 Protein, Human (His) is the recombinant human-derived HACE1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HACE1 Protein, Human (His) is 908 a.a., .

HACE1 是一种 E3 泛素蛋白连接酶，复杂地参与高尔基体膜融合和小 GTP 酶的调节。它在细胞周期期间高尔基体膜动力学中的关键作用涉及 Rab 蛋白招募到高尔基体膜，在那里它协调有丝分裂后高尔基体膜融合。在有丝分裂高尔基体解体过程中，HACE1 介导泛素化，作为细胞分裂后续阶段高尔基体重新组装的关键信号。值得注意的是，HACE1 在与 GTP 结合的 RAC1 相互作用中表现出特异性，导致活性 RAC1 的泛素化和随后的降解。这一功能使 HACE1 成为宿主防御病原体的重要贡献者。此外，HACE1 可能通过与 RARB 相互作用来扩大其作为转录调节因子的影响。

Human

E. coli

N-6*His

Q8IYU2 (E2-A909)

57531

Approximately 104.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH7.5, 200 mM NaCl, 20% glycerol.

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Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.