2. 重组蛋白
  3. Viral Proteins Biotinylated Proteins
  4. Influenza Viruses Proteins
  5. Influenza Hemagglutinin
  6. HA/Hemagglutinin 蛋白, H1N1 (Biotinylated, ACP41105.1, sf9)

HA/Hemagglutinin 蛋白, H1N1 (Biotinylated, ACP41105.1, sf9)

目录号: HY-P77025
产品使用指南

血凝素 (HA) 蛋白对于病毒附着到宿主细胞、与唾液酸受体结合以及通过网格蛋白依赖性或非依赖性途径启动病毒粒子内化至关重要。作为 I 类病毒融合蛋白，HA 决定宿主范围和毒力，介导病毒渗透到细胞质。HA/Hemagglutinin 蛋白, H1N1 (Biotinylated, ACP41105.1, sf9) 是重组的 血凝素/HA 蛋白，由 Sf9 insect cells 表达，不带标签。

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100 μg   询价  

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描述

The hemagglutinin (HA) protein is essential for viral attachment to host cells, binding to sialic acid receptors, and initiating virion internalization through clathrin-dependent or -independent pathways. As a class I viral fusion protein, HA determines host range and virulence, mediating viral penetration into the cytoplasm. Hemagglutinin/HA Protein, H1N1 (Biotinylated, ACP41105.1, sf9) is the recombinant Virus-derived Hemagglutinin/HA protein, expressed by Sf9 insect cells , with tag free.
研究背景

血凝素 (HA) 蛋白是病毒颗粒通过与细胞表面含唾液酸的受体结合而附着到宿主细胞的核心。这种相互作用导致病毒粒子通过网格蛋白依赖性内吞作用或网格蛋白和小窝蛋白独立途径内化。HA 在确定宿主范围限制和毒力方面发挥着关键作用，作为 I 类病毒融合蛋白负责病毒渗透到细胞质中。它介导内吞病毒颗粒膜与内体膜之间的融合对于成功感染至关重要。内体中的酸性环境诱导HA2亚基发生不可逆的构象变化，释放融合疏水肽。一个有能力的融合孔的形成需要几个HA三聚体的协同作用，这突显了HA在病毒进入过程中协调的复杂分子过程。
种属

Virus
表达系统

Sf9 insect cells
标签

Tag Free
蛋白编号

ACP41105.1 (D18-I566)
基因 ID

/
蛋白结构
N-term
HA/Hemagglutinin (D18-I566)
Accession # ACP41105.1
C-term
同用名
Influenza A H1N1 (A/California/04/2009) Hemagglutinin / HA0 Protein (Biotinylated)
氨基酸序列

DTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADTYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNIPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGTYDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQCRICI

分子量

Approximately 61.5 kDa.
纯度

Greater than 85% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

HA/Hemagglutinin Protein, H1N1 (Biotinylated, ACP41105.1, sf9) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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