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  3. HEPACAM2 蛋白, Rat (HEK293, Fc)

HEPACAM2 蛋白, Rat (HEK293, Fc)

目录号: HY-P77378
产品使用指南

HEPACAM2 基因编码一种在有丝分裂中起作用的免疫球蛋白超家族相关的蛋白质。敲低该基因会导致细胞前期停滞、细胞核形态异常和细胞凋亡。HEPACAM2 可作为结肠腺癌预后的生物标志物。HEPACAM2 蛋白, Rat (HEK293, Fc) 是重组的 HEPACAM2 蛋白,由 HEK293 表达,带有 C-hFc 标签。HEPACAM2 蛋白, Rat (HEK293, Fc) 全长 318 个氨基酸,分子量为 66-73 kDa。

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描述

The HEPACAM2 gene encodes a protein associated with an immunoglobulin superfamily that plays a role in mitosis. Knocking down this gene can lead to prophase cell arrest, abnormal nuclear morphology and apoptosis. HEPACAM2 can be used as a biomarker for the prognosis of colorectal adenocarcinoma. HEPACAM2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HEPACAM2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HEPACAM2 Protein, Rat (HEK293, Fc) is 318 a.a., with molecular weight of 66-73 kDa.

研究背景

HepaCAM 是一种编码免疫球蛋白超家族成员的 N-连锁糖蛋白,是一种介导多种细胞生物功能的肿瘤抑制基因。HepaCAM 可能通过 AKT/FoxO 通路作为抑制膀胱癌增殖的新的治疗靶点。HEPACAM2 基因编码一种在有丝分裂中起作用的免疫球蛋白超家族相关的蛋白质。敲低该基因会导致细胞前期停滞、细胞核形态异常和细胞凋亡。编码蛋白的聚 (ADP -核糖基化) 促进其易位到中心体,这可能刺激中心体成熟。包含该基因的染色体缺失可能与人类患者的髓性白血病和骨髓增生异常综合征有关。HEPACAM2 可作为结肠腺癌预后的生物标志物。

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

B5DEN8 (L33-L350)

基因 ID
蛋白结构
N-term
HEPACAM2 (L33-L350)
Accession # B5DEN8
hFc
C-term
同用名
HEPACAM family member 2; Mitotic kinetics regulator; MIKI
分子量

66-73 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

HEPACAM2 Protein, Rat (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HEPACAM2 Protein, Rat (HEK293, Fc)
目录号:
HY-P77378
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