Hepcidin/HAMP 蛋白, Mouse (GST)

The hepcidin/HAMP protein is a liver-produced hormone that is a major regulator of iron absorption and distribution. It promotes endocytosis and degradation of SLC40A1, retaining iron within cells and reducing plasma iron flux. Hepcidin/HAMP Protein, Mouse (GST) is the recombinant mouse-derived Hepcidin/HAMP protein, expressed by E. coli , with N-GST labeled tag. The total length of Hepcidin/HAMP Protein, Mouse (GST) is 25 a.a., with molecular weight of 29.4 kDa.

铁调素是一种肝脏产生的激素，是控制铁在全身的吸收和分布的主要循环调节剂。其调节机制涉及促进内吞作用和 SLC40A1 的降解，导致铁保留在铁输出细胞内，从而减少流入血浆的铁。铁调素协调重要的铁通量，包括肠道中膳食铁的吸收、巨噬细胞通过吞噬老化红细胞和其他细胞来回收铁，以及从肝细胞中动员储存的铁。它与 SLC40A1 的相互作用触发后者的快速泛素化，强调了铁调素在维持铁稳态中的关键作用。

Mouse

E. coli

N-GST

Q9EQ21 (D59-T83)

84506  [NCBI]

DTNFPICIFCCKCCNNSQCGICCKT

29.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.