2. Gene
  3. Hamp - hepcidin antimicrobial peptide Gene

Hamp - hepcidin antimicrobial peptide Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hepc; Hamp1; Hepc1

基因 ID: 84506 | 基因类型: protein coding

关于 Hamp

功能概要

This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature Peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]

Hamp 基因产物(1)

mRNA Protein Name
NM_032541.2 NP_115930.1 hepcidin preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables copper ion binding IDA
IDA: 通过直接分析推断
20113314 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
20530874 MGI
acts upstream of or within defense response to bacterium IDA
IDA: 通过直接分析推断
11113131 MGI
acts upstream of or within defense response to bacterium IMP
IMP: 通过突变表型推断
23390527 MGI
acts upstream of or within defense response to fungus IDA
IDA: 通过直接分析推断
2995362 MGI
acts upstream of establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
21700773 MGI
acts upstream of inflammatory response IGI
IGI: 通过遗传相互作用推断
20530874 MGI
involved in intracellular iron ion homeostasis IDA
IDA: 通过直接分析推断
11447267 MGI
acts upstream of iron ion transmembrane transport IGI
IGI: 通过遗传相互作用推断
21700773 MGI
acts upstream of macrophage activation IMP
IMP: 通过突变表型推断
22383698 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IDA
IDA: 通过直接分析推断
20113314 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
16574947 MGI
acts upstream of or within myeloid cell homeostasis IMP
IMP: 通过突变表型推断
24357729 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: 通过突变表型推断
24561287 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
20530874 MGI
acts upstream of or within negative regulation of iron ion transmembrane transport IGI
IGI: 通过遗传相互作用推断
21700773 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18539898 MGI
acts upstream of or within positive regulation of macrophage activation IMP
IMP: 通过突变表型推断
22383698 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
21700773 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
18800028 MGI
acts upstream of protein catabolic process IDA
IDA: 通过直接分析推断
21700773 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
18800028 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
11447267 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
17435114 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11113132 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hepcidin

hepcidin antimicrobial peptide 1

重组 Hamp 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700634 Hepcidin/HAMP Protein, Mouse (GST) Q9EQ21 (D59-T83) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05995 HAMP Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990429 Anti-Hepcidin/HAMP Antibody Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hamp NCBI NCBI:57817
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