2. 重组蛋白
  3. Cytokines and Growth Factors CAR-T related Proteins CD Antigens Receptor Proteins Enzymes & Regulators
  4. EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. ErbB2/HER2 EGFR/ErbB family
  6. HER2/CD340 蛋白, Cynomolgus (HEK293, Fc)

HER2/CD340 蛋白, Cynomolgus (HEK293, Fc)

目录号: HY-P75804
产品使用指南

Erb-b2 receptor tyrosine kinase 2 是 EGFR 家族的一员。Erb-b2 receptor tyrosine kinase 2 在许多类型癌症的肿瘤中过度表达。Erb-b2 receptor tyrosine kinase 2 使 ATP 结合和激活跨膜受体蛋白酪氨酸激酶活性。HER2/CD340 蛋白, Cynomolgus (HEK293, Fc) 是重组的 HER2/CD340 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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规格 是否有货
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100 μg   询价  

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描述

Erb-b2 receptor tyrosine kinase 2 is a member of EGFR family. Erb-b2 receptor tyrosine kinase 2 is over-expressed in the tumors of many types of cancers. Erb-b2 receptor tyrosine kinase 2 enables ATP binding and transmembrane receptor protein tyrosine kinase activity. HER2/CD340 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived HER2/CD340 protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

Erb-b2 receptor tyrosine kinase 2 能使ATP结合和激活跨膜受体蛋白酪氨酸激酶活性。Erb-b2 receptor tyrosine kinase 2 参与多细胞生物发育、神经元分化、MAPK级联的正向调节、细胞群增殖的正向调节、激酶活性的正向调节、蛋白磷酸化及跨膜受体蛋白酪氨酸激酶信号通路。Erb-b2 receptor tyrosine kinase 2 定位于基底膜[1][2][3]。
种属

Cynomolgus
表达系统

HEK293
标签

C-hFc
蛋白编号

XP_005584091.2 (T23-T652, D121N)
基因 ID

/
蛋白结构
N-term
HER2 (T23-T652, D121N)
Accession # XP_005584091.2
hFc
C-term
同用名
Receptor tyrosine-protein kinase erbB-2; p185neu; CD340; Erbb2; Neu
氨基酸序列

TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGNPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPVCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLRVFETLEEITGYLYISAWPDSLPDLSVLQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTRLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGTCQSCPINCTHSCVDLDDKGCPAEQRASPLT

分子量

Approximately 96.4 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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