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  5. HER3 蛋白, Human (HEK293, His-Avi)

HER3 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78452
产品使用指南

HER3 是一种关键的酪氨酸蛋白激酶,是神经调节蛋白的重要细胞受体。Neuregulin-1 (NRG1) 激活可促进酪氨酸磷酸化以及与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。CSPG5 也可能激活 HER3。它参与骨髓细胞分化,强调了 HER3 在正常发育和功能的重要细胞过程中的重要作用。HER3 蛋白, Human (HEK293, His-Avi) 是重组的 HER3 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。

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描述

HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

研究背景

HER3 是一种酪氨酸蛋白激酶,是神经调节蛋白的关键细胞表面受体。由神经调节蛋白-1 (NRG1) 激活,配体结合增强酪氨酸残基的磷酸化,并促进其与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。此外,有证据表明 CSPG5 可以激活。HER3 错综复杂地参与骨髓细胞分化的调节,突出了其在对正常发育和功能至关重要的细胞过程中的关键作用。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

P21860-1 (S20-T643)

基因 ID
蛋白结构
N-term
HER3 (S20-T643)
Accession # P21860-1
His-Avi
C-term
同用名
ErbB3; ErbB-3; HER3; HER3c-erbB-3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; ERBB3
分子量

72-75 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HER3 Protein, Human (HEK293, His-Avi)
目录号:
HY-P78452
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