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  5. HER3 蛋白, Human (sf9, His-GST)

HER3 蛋白, Human (sf9, His-GST)

目录号: HY-P74893
产品使用指南

HER3 是一种关键的酪氨酸蛋白激酶,是神经调节蛋白的重要细胞受体。Neuregulin-1 (NRG1) 激活可促进酪氨酸磷酸化以及与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。CSPG5 也可能激活 HER3。它参与骨髓细胞分化,强调了 HER3 在正常发育和功能的重要细胞过程中的重要作用。HER3 蛋白, Human (sf9, His-GST) 是重组的 HER3 蛋白,由 Sf9 insect cells 表达,带有 N-His, N-GST 标签。

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描述

HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (sf9, His-GST) is the recombinant human-derived HER3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

研究背景

HER3 是一种酪氨酸蛋白激酶,是神经调节蛋白的关键细胞表面受体。由神经调节蛋白-1 (NRG1) 激活,配体结合增强酪氨酸残基的磷酸化,并促进其与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。此外,有证据表明 CSPG5 可以激活。HER3 错综复杂地参与骨髓细胞分化的调节,突出了其在对正常发育和功能至关重要的细胞过程中的关键作用。

种属

Human

表达系统

Sf9 insect cells

标签

N-His;N-GST

蛋白编号

P21860-1/NP_001973.2 (P730-S1065)

基因 ID
蛋白结构
N-term
His-GST
HER3 (P730-S1065)
Accession # P21860-1/NP_001973.2
C-term
同用名
Receptor tyrosine-protein kinase erbB-3; ERBB3; HER3
分子量

Approximately 65 kDa

纯度

Greater than 80% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HER3 Protein, Human (sf9, His-GST)
目录号:
HY-P74893
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