HO-1 蛋白, Human

HO-1 Protein, an enzyme, plays a critical role in cellular defense against oxidative stress and inflammation. Dysregulation of HO-1 Protein has been implicated in several diseases, including cardiovascular disorders and neuroinflammatory conditions. Targeting HO-1 Protein may offer potential therapeutic interventions by enhancing antioxidant defenses, reducing inflammation, and potentially treating these diseases. HO-1 Protein, Human is the recombinant human-derived HO-1 protein, expressed by E. coli , with tag free. The total length of HO-1 Protein, Human is 261 a.a., with molecular weight of ~30.0 kDa.

HO-1 蛋白充当血红素在 α-亚甲基桥碳处氧化裂解的催化剂，导致一氧化碳 (CO) 的释放和胆绿素 IXα 的生成，同时以亚铁形式释放中央血红素铁螯合物铁。该过程已在各种出版物中得到广泛记录。此外，HO-1 蛋白通过分解代谢游离血红素，从而防止其使细胞敏感和诱导细胞凋亡的能力，从而在防止程序性细胞死亡方面发挥着至关重要的作用。大量研究证实了HO-1蛋白的细胞保护作用。此外，在微生物感染的情况下，据观察，在 SARS-CoV-2 感染期间，HO-1 蛋白促进 SARS-CoV-2 ORF3A 介导的自噬，尽管它被认为对于 ORF3A 诱导网状自噬不是必需的。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

Tag Free

P09601 (M1-T261)

3162  [NCBI]

MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNT

Approximately 30.8 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.