HO-2/HMOX2 蛋白, Human (His)

Through its catalytic activity, HO-2/HMOX2 protein promotes the oxidative cleavage of heme at the α-methylene bridge carbon, thereby releasing carbon monoxide (CO). This process simultaneously produces biliverdin IXalpha and releases the central heme iron chelate in the form of ferrous iron. HO-2/HMOX2 Protein, Human (His) is the recombinant human-derived HO-2/HMOX2 protein, expressed by E. coli , with C-6*His labeled tag.

血红素加氧酶-2 (HO-2) 由 HMOX2 基因编码，是一种关键酶，可催化 α-亚甲基桥碳处血红素的氧化裂解，导致一氧化碳 (CO) 的释放和胆绿素的生成IXα。同时，酶将中心血红素铁螯合物释放为二价铁。该反应代表血红素分解代谢的关键步骤，并作为维持细胞血红素稳态的调节机制。一氧化碳和胆绿素的释放以及二价铁的释放强调了 HO-2 在气体递质信号传导和铁的循环利用中的多功能作用。HO-2 的酶活性对于多种生理过程至关重要，包括抗氧化防御、抗炎反应和血管张力调节。

Measured by its ability to oxidize hemin to biliverdin. The specific activity is >3.5 pmol/min/μg.

Human

E. coli

C-6*His

P30519-1 (S2-L291)

3163  [NCBI]

SAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQAGSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVL

Approximately 31 & 35 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.