IDS/Iduronate 2-sulfatase 蛋白, Human (HEK293, His)

IDS/Iduronate 2-sulfatase Protein, a lysosomal enzyme, participates in the degradation pathway of dermatan sulfate and heparan sulfate. IDS/Iduronate 2-sulfatase Protein, Human (HEK293, His) is the recombinant human-derived IDS/Iduronate 2-sulfatase protein, expressed by HEK293 , with C-His labeled tag. The total length of IDS/Iduronate 2-sulfatase Protein, Human (HEK293, His) is 525 a.a., with molecular weight (glycosylation form) of ~75-95 kDa.

IDS（艾杜糖醛酸2-硫酸酯酶）是一种溶酶体酶，在硫酸皮肤素和硫酸乙酰肝素的降解途径中发挥着至关重要的作用。作为细胞代谢的重要组成部分，IDS 促进溶酶体内这些糖胺聚糖的分解，有助于维持正常的细胞功能和组织稳态。IDS 的酶活性对于硫酸皮肤素和硫酸乙酰肝素的分解代谢至关重要，可防止它们在溶酶体内积聚并确保正常的细胞过程。这强调了 IDS 在参与糖胺聚糖降解的复杂代谢途径网络中的关键作用。

Human

HEK293

C-10*His

P22304-1 (S26-P550)

3423  [NCBI]

SETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP

Approximately 75-95 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.