Ig Lambda Constant 2 蛋白, Human (HEK293, His)

The Ig Lambda Constant 2 protein is part of the constant region of the immunoglobulin light chain. It acts as a receptor during the recognition phase of humoral immunity, triggering B lymphocyte expansion and differentiation into plasma cells. Ig Lambda Constant 2 Protein, Human (HEK293, His) is the recombinant human-derived Ig Lambda Constant 2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ig Lambda Constant 2 Protein, Human (HEK293, His) is 106 a.a., with molecular weight of ~16.0 kDa.

免疫球蛋白轻链的恒定区，特别是 Ig Lambda Constant 2 蛋白，是抗体结构的组成部分，也称为免疫球蛋白。这些膜结合或分泌的糖蛋白由 B 淋巴细胞产生，在体液免疫识别阶段充当受体。结合特定抗原后，膜结合免疫球蛋白会促使 B 淋巴细胞克隆扩增并分化为分泌免疫球蛋白的浆细胞。反过来，分泌的免疫球蛋白在体液免疫的效应阶段发挥关键作用，促进结合抗原的消除。抗原结合位点由一条重链的可变结构域及其相关轻链的可变结构域精心策划，导致每种免疫球蛋白拥有两个对特定抗原具有显着亲和力的抗原结合位点。可变结构域经历 V-(D)-J 重排和随后的体细胞超突变，从而在暴露于抗原和选择后实现亲和力成熟。免疫球蛋白由两条相同的重链和两条相同的轻链组成，通过二硫键互连。

Human

HEK293

C-6*His

P0DOY2 (G1-S106)

3538  [NCBI]

GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

Approximately 16.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.