1. 重组蛋白
  2. Cytokines and Growth Factors
  3. IGF family
  4. Insulin-like Growth Factor 2 (IGF-II)
  5. IGF2 蛋白, Human (GST)

IGF2 蛋白, Human (GST)

目录号: HY-P700475
产品使用指南

IGF2蛋白是胰岛素样生长因子家族的重要成员,在哺乳动物生长、胎儿胎盘发育和成人葡萄糖代谢中发挥重要作用。受胎盘催乳素调节,影响组织分化。IGF2 蛋白, Human (GST) 是重组的 IGF2 蛋白,由 E. coli 表达,带有 N-GST 标签。

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描述

The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. IGF2 Protein, Human (GST) is the recombinant human-derived IGF2 protein, expressed by E. coli , with N-GST labeled tag.

研究背景

IGF2 蛋白是胰岛素样生长因子家族的一员,在促进生长和影响胎儿胎盘发育方面发挥着关键作用,特别是作为哺乳动物的主要胎儿生长激素。它受胎盘催乳素调节并有助于组织分化。在成人中,IGF2 参与脂肪组织、骨骼肌和肝脏的葡萄糖代谢。作为整合素的配体,它促进 IGF2 信号传导并正向调节生肌转录因子 MYOD1 的功能,从而控制肌肉终末分化。此外,IGF2 通过增加线粒体呼吸速率来抑制成肌细胞分化并调节新陈代谢。此外,在葡萄糖介导的胰岛素共同分泌中,IGF2的对应物preptin充当葡萄糖介导的胰岛素分泌的生理放大器。值得注意的是,IGF2 具有成骨特性,通过磷酸化 MAPK1 和 MAPK3 增强成骨细胞有丝分裂活性。

种属

Human

表达系统

E. coli

标签

N-GST

蛋白编号

P01344-1 (E30-K180)

基因 ID
蛋白结构
N-term
GST
IGF2 (E30-K180)
Accession # P01344-1
C-term
同用名
insulin-like growth factor 2 (somatomedin A); INSIGF; pp9974; C11orf43; FLJ22066; FLJ44734; IGF2; insulin-like growth factor 2; IGF-II; somatomedin A; somatomedin-A; insulin-like growth factor II; insulin-like growth factor type 2; putative insulin-like growth factor II associated protein; chromosome 11 open reading frame 43; OTTHUMP00000011157; OTTHUMP00000011018
氨基酸序列

ETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK

分子量

44.1 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IGF2 Protein, Human (GST)
目录号:
HY-P700475
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